Brief Reports
Copyright ©2005 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 14, 2005; 11(6): 871-874
Published online Feb 14, 2005. doi: 10.3748/wjg.v11.i6.871
Clinical significance of matrix metalloproteinase-9 expression in esophageal squamous cell carcinoma
Zhen-Dong Gu, Ke-Neng Chen, Ming Li, Jin Gu, Ji-You Li
Zhen-Dong Gu, Ke-Neng Chen, Department of Thoracic Surgery, Peking University School of Oncology, Beijing Cancer Hospital, Beijing 100036, China
Ming Li, Jin Gu, Department of General Surgery, Peking University School of Oncology, Beijing Cancer Hospital, Beijing 100036, China
Ji-You Li, Department of Pathology, Peking University School of Oncology, Beijing Cancer Hospital, Beijing 100036, China
Author contributions: All authors contributed equally to the work.
Supported by the Research Fund of Beijing Municipal Science and Technology Commission, No. H020920030390
Correspondence to: Ji-You Li, Professor of Department of Pathology, Peking University School of Oncology, Beijing Cancer Hospital, Beijing 100036, China. lijiyou@263.net
Telephone: +86-10-88121122 Fax: +86-10-88122437
Received: August 18, 2004
Revised: August 21, 2004
Accepted: October 7, 2004
Published online: February 14, 2005
Abstract

AIM: To evaluate the expression of matrix metalloproteinase-9 (MMP-9) and its clinical significance in esophageal squamous cell carcinoma (ESCC).

METHODS: The expression of MMP-9 in 208 cases of ESCC was detected by immunohistochemistry (IHC) and its clinical significance in ESCC especially the relationship with the clinicopathological parameters was analyzed.

RESULTS: The percentage of positive cases for MMP-9 detected by IHC was 49.0%. MMP-9 was mainly expressed in the cytoplasm of cancer cells especially in the invasive front. Only weak expression was detected in the stromal cells and no expression in non-cancerous mucosa. The expression of MMP-9 was positively correlated with poorer differentiation (P = 0.001<0.01), existence of vessel permeation (P = 0.027<0.05) and lymph node metastasis (P = 0.027<0.05).

CONCLUSION: The expression of MMP-9 correlates with the cancer cell differentiation, vessel permeation and lymph node metastasis. It may be a novel biomarker for the diagnosis and treatment of ESCC.

Keywords: Matrix metalloproteinase-9; Esophageal squamous cell carcinoma; Immunohistochemistry; Clinicopathological parameters; Biomarker