Ji YB, Gao SY, Cheng WP. Effect of Haimiding on the functioning of red cell membrane of FC and H22 tumor-bearing mice. World J Gastroenterol 2005; 11(6): 823-830 [PMID: 15682474 DOI: 10.3748/wjg.v11.i6.823]
Corresponding Author of This Article
Dr. Yu-Bin Ji, Postdoctoral Research Station, The Institute of Materia Medica, Harbin Commercial University, 138 Tongda Street, Daoli District, Harbin 150076, Heilongjiang Province, China. sygao2002@sina.com
Article-Type of This Article
Basic Research
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Feb 14, 2005; 11(6): 823-830 Published online Feb 14, 2005. doi: 10.3748/wjg.v11.i6.823
Effect of Haimiding on the functioning of red cell membrane of FC and H22 tumor-bearing mice
Yu-Bin Ji, Shi-Yong Gao, Wei-Ping Cheng
Yu-Bin Ji, Shi-Yong Gao, Wei-Ping Cheng, Postdoctoral Research Station, Institute of Materia Medica, Harbin Commercial University, Harbin 150076, Heilongjiang Province, China
Author contributions: All authors contributed equally to the work.
Supported by National Science Foundation of China (No. 30271598, 30300284); Heilongjiang Science Foundation (No. ZJY03-04); Ministry of Information Industry (No. 01XK230002); Heilongjiang Department of Education (Major Project No. 9551z006); Innovative Fund for Distinguished University and College Teachers of Heilongjiang Province, No. 2001015
Correspondence to: Dr. Yu-Bin Ji, Postdoctoral Research Station, The Institute of Materia Medica, Harbin Commercial University, 138 Tongda Street, Daoli District, Harbin 150076, Heilongjiang Province, China. sygao2002@sina.com
Telephone: +86-451-84866001 Fax: +86-451-84866001
Received: August 18, 2004 Revised: August 21, 2004 Accepted: September 17, 2004 Published online: February 14, 2005
Abstract
AIM: To study the effect of Haimiding on the functioning of red cell membrane of FC and H22 tumor-bearing mice.
METHODS: The membrane fluidity of red cells is measured with DPH fluorescence probe as a marker; the amount of red cell membrane proteins is measured using polyacrylamide gel electrophoresis; the amount of sialic acid (SA) on the surface of red cell membrane and the sealability of these cells are measured using colorimetric analysis.
RESULTS: Haimiding can lower the membrane fluidity of red cells in tumor-bearing mice and the amount of their membrane proteins, while increasing the amount of sialic acid in the membrane of red cells in these mice and enhancing the ability of the membrane of their red cells to reseal.
CONCLUSION: The anti-tumor effect of Haimiding on tumor-bearing mice is due to its ability to improve and restore the functions of the membrane of their red cell and to enhance the immune effect of the organisms.
