Effects of Helicobacter pylori eradication on atrophic gastritis and intestinal metaplasia: A 3-year follow-up study

doi:10.3748/wjg.v11.i41.6518

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 7, 2005; 11(41): 6518-6520
Published online Nov 7, 2005. doi: 10.3748/wjg.v11.i41.6518

Effects of Helicobacter pylori eradication on atrophic gastritis and intestinal metaplasia: A 3-year follow-up study

Bin Lu, Ming-Tao Chen, Yi-Hong Fan, Yan Liu, Li-Na Meng

Bin Lu, Ming-Tao Chen, Yi-Hong Fan, Yan Liu, Li-Na Meng, Department of Gastroenterology, Affiliated Hospital of Zhejiang Traditional Chinese Medicine College, Hangzhou 310006, Zhejiang Province, China

Author contributions: All authors contributed equally to the work.

Supported by the Scientific Research Fund of the Health Bureau of Zhejiang Province, No. 2001QN012

Correspondence to: Dr. Bin Lu, Department of Gastroenterology, Affiliated Hospital of Zhejiang Traditional Chinese Medicine College, Hangzhou 310006, Zhejiang Province China. lvbin@medmail.com.cn

Telephone: +86-571-87032028 Fax: +86-571-87077785

Received: December 28, 2004
Revised: March 21, 2005
Accepted: March 24, 2005
Published online: November 7, 2005

Abstract

AIM: To investigate the effect of H pylori eradication on atrophic gastritis and intestinal metaplasia (IM).

METHODS: Two hundred and fifty-nine patients with atrophic gastritis in the antrum were included in the study, 154 patients were selected for H pylori eradication therapy and the remaining 105 patients served as untreated group. Gastroscopy and biopsies were performed both at the beginning and at the end of a 3-year follow-up study. Gastritis was graded according to the updated Sydney system.

RESULTS: One hundred and seventy-nine patients completed the follow-up, 92 of them received H pylori eradication therapy and the remaining 87 H pylori-infected patients were in the untreated group. Chronic gastritis, active gastritis and the grade of atrophy significantly decreased in H pylori eradication group (P<0.01). However, the grade of IM increased in H pylori -infected group (P<0.05).

CONCLUSION: H pylori eradication may improve gastric mucosal inflammation, atrophy and prevent the progression of IM.

Keywords: H pylori, Atrophic gastritis, Intestinal metaplasia