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©The Author(s) 2005. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 21, 2005; 11(39): 6085-6089
Published online Oct 21, 2005. doi: 10.3748/wjg.v11.i39.6085
Published online Oct 21, 2005. doi: 10.3748/wjg.v11.i39.6085
Chronic hepatitis C virus infection and post-liver transplantation diabetes mellitus
Yun Ma, Basement 3 The Marco Polo Hotel, 6 Xuanwumen Nei Avenue, Xicheng District, Beijing 10003, China
Wen-Wei Yan, Department of Organ Transplantation, Tianjin First Central Hospital, Tianjin 300192, China
Author contributions: All authors contributed equally to the work.
Correspondence to: Wen-Wei Yan, MD, Department of Organ Transplantation, Tianjin First Central Hospital, Tianjin 300192, China. wenweiyanboy@yahoo.com
Telephone: +86-22-23626549 Fax: +86-22-23682662
Received: March 1, 2005
Revised: April 8, 2005
Accepted: April 11, 2005
Published online: October 21, 2005
Revised: April 8, 2005
Accepted: April 11, 2005
Published online: October 21, 2005
Abstract
Patients with chronic hepatitis C virus (HCV) infection have a significantly increased prevalence of type 2 diabetes mellitus compared to controls or HBV-infected patients. Moreover, the incidence rate of post-liver transplantation diabetes mellitus (PTDM) also appears to be higher among patients with HCV infection. PTDM is often associated with direct viral infection, autoimmune disorders, and immunosuppressive regimen. Activation of tumor necrosis factor-α may be the link between HCV infection and diabetes. In this article, we reviewed the epidemiologic association between HCV infection and PTDM, highlighting the most recent pathophysiologic insights into the mechanisms underlying this association.
Keywords: Hepatitis C virus, Post-liver transplantation diabetes mellitus, Tumor necrosis factor, Immunosupp-ressive therapy