Brief Reports
Copyright ©The Author(s) 2005. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 21, 2005; 11(31): 4857-4860
Published online Aug 21, 2005. doi: 10.3748/wjg.v11.i31.4857
Intra-familial prevalence of hepatitis B virologic markers in HBsAg positive family members in Nahavand, Iran
Amir Houshang Mohammad Alizadeh, Mitra Ranjbar, Shahin Ansari, Seyed Moayed Alavian, Hamid Mohaghegh Shalmani, Leila Hekmat, Mohammad Reza Zali
Amir Houshang Mohammad Alizadeh, Shahin Ansari, Hamid Mohaghegh Shalmani, Mohammad Reza Zali, Research Center for Gastroenterology and Liver Disease, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
Mitra Ranjbar, Leila Hekmat, Hemedan University of Medical Sciences, Iran
Seyed Moayed Alavian, Baghiatallah University of Medical Sciences, Tehran, Iran
Author contributions: All authors contributed equally to the work.
Correspondence to: Amir Houshang, Mohammad Alizadeh, Research Center for Gastroenterology and Liver Disease, Shaheed Beheshti University of Medical Sciences, 7th Floor, Taleghani Hospital, Yaman Street, Evin, Tehran 19857, Iran. article@rcgld.org
Telephone: +98-21-2418871 Fax: +98-21-2402639
Received: December 20, 2005
Revised: January 1, 2005
Accepted: January 5, 2005
Published online: August 21, 2005
Abstract

AIM: To determine the prevalence of hepatitis B in Nahavand and evaluate the HBsAg positive prevalence in families with a member who was confirmed to have HBV infection.

METHODS: This study was performed in two phases. In the first phase, 1 824 subjects in Nahavand city were selected. The interviewers visited the houses of chosen families to fill the questionnaire and take the blood samples. All subjects signed an informed consent before interviews and blood sampling. The samples were evaluated for HBV virologic markers. In the second phase, 115 HBsAg-positive cases were enrolled and evaluated for HBV virologic markers.

RESULTS: The prevalence of positive HBsAg in Nahavand was 2.3%. The most frequent relatives of index cases were sons and daughters (32.2% and 23.5% respectively). Twelve (11%) of all family members were HBsAg positive. Fifty (56.2%) were isolated HBsAb positive and only one person (2.5%) was isolated HBcAb positive. The higher rates of HBsAg marker were detected in the brothers (1-25%) and fathers (1-12.5%). The infection rate in husbands and wives of index cases was 10%. Only two (16.7%) of all HBsAg-positive participants reported previous HBV vaccination.

CONCLUSION: The prevalence of intra-familial HBV infection is lower in Nahavand of Iran compared to other studies. More attention should be paid to HBV vaccination and risk-lowering activities.

Keywords: Intra-familial prevalence, Hepatitis B, Nahavand, Iran