Influence of HLA-DRB1 alleles and HBV genotypes on interferon-&alpha; therapy for chronic hepatitis B

doi:10.3748/wjg.v11.i30.4753

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Aug 14, 2005; 11(30): 4753-4757
Published online Aug 14, 2005. doi: 10.3748/wjg.v11.i30.4753

Influence of HLA-DRB1 alleles and HBV genotypes on interferon-α therapy for chronic hepatitis B

Rui-Hai Chu, Li-Xian Ma, Gang Wang, Li-Hua Shao

Rui-Hai Chu, Li-Xian Ma, Gang Wang, Li-Hua Shao, Department of Infectious Diseases, Qilu Hospital of Shandong University, Jinan 250012, Shandong Province, China

Author contributions: All authors contributed equally to the work.

Correspondence to: Dr. Rui-Hai Chu, Department of Infectious Diseases, Qilu Hospital of Shandong University, Jinan 250012, Shandong Province, China. rhchu@163.com

Telephone: +86-531-8380313

Received: July 12, 2004
Revised: August 23, 2004
Accepted: August 25, 2004
Published online: August 14, 2005

Abstract

AIM: To investigate the influence of HLA-DRB₁ alleles and HBV genotypes on interferon-α therapy for chronic hepatitis B.

METHODS: HLA-DRB1*03, *07, *09, *12, *15 alleles were determined using polymerase chain reaction/sequence specific primer (PCR/SSP) technique in 126 patients with chronic hepatitis B and 76 normal control subjects in Shandong Province, and HBV genotypes were determined by nested-PCR analysis using type-specific primers in 126 patients.

RESULTS: The positivity of HLA-DRB1*07 allele in chronic hepatitis B group was significantly higher than that in normal control group (χ² = 6.33, P < 0.025, RR = 2.37). Among the 126 patients, genotype B was found in 38 (30.2%), genotype C in 69 (54.8%), and mixed genotype (B+C) in 19 (15.0%), genotypes D-F were not found. Among the 46 DRB1*07(+) patients, 7 were responders and 39 were non-responders among them (χ² = 6.71, P < 0.05). The positivity of HLA-DRB1*07 and prevalence of HBV genotype C were significantly higher in non-responders than in responders.

CONCLUSION: High positivities of HLA-DRB1 ^*07 allele and HBV genotype C are closely associated with the lower response to interferon-α therapy for chronic hepatitis B.

Keywords: HLA-DRB1 alleles, HBV genotypes, Interferon-α therapy, Chronic hepatitis B