Ding X, Yang LY, Huang GW, Yang JQ, Liu HL, Wang W, Peng JX, Yang JQ, Tao YM, Chang ZG, Ling XS. Role of AFP mRNA expression in peripheral blood as a predictor for postsurgical recurrence of hepatocellular carcinoma: A systematic review and meta-analysis. World J Gastroenterol 2005; 11(17): 2656-2661 [PMID: 15849829 DOI: 10.3748/wjg.v11.i17.2656]
Corresponding Author of This Article
Lian-Yue Yang, Department of General Surgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China. lianyueyang@hotmail.com
Article-Type of This Article
Brief Reports
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. May 7, 2005; 11(17): 2656-2661 Published online May 7, 2005. doi: 10.3748/wjg.v11.i17.2656
Role of AFP mRNA expression in peripheral blood as a predictor for postsurgical recurrence of hepatocellular carcinoma: A systematic review and meta-analysis
Xiang Ding, Lian-Yue Yang, Geng-Wen Huang, Jian-Qing Yang, He-Li Liu, Wei Wang, Ji-Xiang Peng, Jie-Quan Yang, Yi-Ming Tao, Zhi-Gang Chang, Liver Cancer Laboratory, Department of General Surgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China
Xiu-Shou Ling, Department of Epidemiology, Xiangya Medical College, Central South University, Changsha 410078, Hunan Province, China
Author contributions: All authors contributed equally to the work.
Supported by the National Key Research and Development Program, No. 2001BA703BO4
Correspondence to: Lian-Yue Yang, Department of General Surgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China. lianyueyang@hotmail.com
Telephone: +86-731-4327326 Fax: +86-731-4327332
Received: April 10, 2004 Revised: April 11, 2004 Accepted: May 13, 2004 Published online: May 7, 2005
Abstract
AIM: To identify the role of alpha-fetoprotein (AFP) mRNA expression in peripheral blood one week after surgery as a predictor for recurrence of hepatocellular carcinoma (HCC).
METHODS: Published studies fulfilling the selection criteria were identified by searching several databases online. After a methodology assessment using a quality scale designed by European Lung Cancer Working Party, data in each research were aggregated by means of meta-analysis.
RESULTS: Altogether 368 cases were included in the 9 selected studies, which fulfilled the selection criteria. The quality scores ranged from 35% to 84% with a median score of 55%. The ‘design’ subscore had the lowest median value (38%). By aggregating the data, a high χ2 value (77.576) was presented. The fail-safe number was 136 and 64 for P = 0.05 and 0.01, respectively.
CONCLUSION: AFP mRNA expression in peripheral blood 1 wk after surgery correlated with the recurrence of HCC and was a good predictor for tumor recurrence.
