14C-urea breath test in patients undergoing anti-tuberculosis therapy

doi:10.3748/wjg.v11.i11.1712

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 21, 2005; 11(11): 1712-1714
Published online Mar 21, 2005. doi: 10.3748/wjg.v11.i11.1712

¹⁴C-urea breath test in patients undergoing anti-tuberculosis therapy

Sayed Amir Mirbagheri, Amir Ali Sohrabpour, Mehrdad Hasibi, Babak Moghimi, Mehdi Mohamadnejad

Sayed Amir Mirbagheri, Babak Moghimi, Department of Gastroenterology, Amir-Alam General Hospital, Tehran University of Medical Sciences, Tehran, Iran

Amir Ali Sohrabpour, Digestive Disease Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

Mehrdad Hasibi, Department of Infectious Diseases, Amir-Alam General Hospital, Tehran University of Medical Sciences, Tehran, Iran

Mehdi Mohamadnejad, GI and Liver Disease Research Center, Iran University of Medical Sciences, Tehran, Iran

Author contributions: All authors contributed equally to the work.

Correspondence to: Amir Ali Sohrabpour, Digestive Disease Research Center, Tehran University of Medical Sciences, Shariati Hospital, 14114 , Kargar Shomali Ave, Tehran, Iran. sohrabpour@ddrcir.org

Telephone: +98-21-8012992 Fax: +98-21-8026481

Received: August 17, 2004
Revised: August 18, 2004
Accepted: September 6, 2004
Published online: March 21, 2005

Abstract

AIM: Urea breath test (UBT) is a non-invasive diagnostic test for detecting the presence of Helicobacter pylori (H pylori). In this study we evaluated the effect of anti-tuberculosis therapy on the results of ¹⁴C-UBT.

METHODS: Patients, with the diagnosis of tuberculosis (TB) who had a positive UBT at the point of starting anti-TB therapy, were included. None had a history of peptic ulcer disease or had taken antibiotics, bismuth compounds and/or PPI in the previous month. ¹⁴C-UBT was repeated at the end of the second month and the end of treatment period and one month after completion of treatment course.

RESULTS: Thirty-five patients (23 males) were enrolled. ¹⁴C-UBT was negative in all 35 patients (100%) at the end of the second month and remained negative in 30 cases (85.7%) at the end of the treatment course. One month after completion of treatment course, UBT remained negative in 13 patients (37.1%).

CONCLUSION: Our report underscores the need for caution while interpreting urea breath test results in patients undergoing anti-TB therapy. Furthermore, the combination of drugs used in this study resulted in H pylori eradication in a minority of patients.

Keywords: Urea breath test (UBT), Helicobacter pylori, Tuberculosis