Point mutation of 5&rsquo; noncoding region of BCL-6 gene in primary gastric lymphomas

doi:10.3748/wjg.v11.i1.51

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Gastric Cancer

World J Gastroenterol. Jan 7, 2005; 11(1): 51-55
Published online Jan 7, 2005. doi: 10.3748/wjg.v11.i1.51

Point mutation of 5’ noncoding region of BCL-6 gene in primary gastric lymphomas

Da-Liu Min, Xiao-Yan Zhou, Wen-Tao Yang, Hong-Fen Lu, Tai-Ming Zhang, Ai-Hua Zhen, Pei-Zheng Cao, Da-Ren Shi

Da-Liu Min, Xiao-Yan Zhou, Wen-Tao Yang, Hong-Fen Lu, Tai-Ming Zhang, Ai-Hua Zhen, Pei-Zheng Cao, Da-Ren Shi, Laboratory of Molecular Pathology, Cancer Hospital of Fudan University, Shanghai 200032, China

Author contributions: All authors contributed equally to the work.

Supported by National Natural Science Foundation of China, No.39900065

Correspondence to: Dr. Xiao-Yan Zhou, Laboratory of Molecular Pathology, Cancer Hospital of Fudan University, Shanghai 200032, China. xyzhou100@yahoo.com

Telephone: +86-21-64175590-3646

Received: December 17, 2003
Revised: December 18, 2003
Accepted: January 12, 2004
Published online: January 7, 2005

Abstract

AIM: To investigate the mutations of the 5’ noncoding region of BCL-6 gene in Chinese patients with primary gastric lymphomas.

METHODS: PCR and direct DNA sequencing were used to identify BCL-6 gene mutations in the 5’ noncoding region in 29 cases of gastric diffuse large B-cell lymphoma (DLBCL) and 18 cases of gastric mucosa-associated lymphoid tissue (MALT) lymphoma as well as 10 cases of reactive hyperplasia of lymph node (LRH).

RESULTS: Six of 29 gastric DLBCLs (20.7%), 4 of 18 gastric MALT lymphomas (22.2%) and 1 of 10 LRHs(10%) were found to have mutations. All mutations were single-base substitutions and the frequency of single-base changes was 0.20×10^-2 -1.02×10^-2 per bp.

CONCLUSION: Point mutations in the 5’ noncoding region of BCL-6 gene are found in Chinese patients with primary gastric DLBCLs and MALT lymphomas, suggesting that they may, in some extent, participate in the pathogenesis of primary gastric DLBCLs and MALT lymphomas.

Keywords: Gastric lymphomas, BCL-6 gene, 5’ noncoding region, Point mutation