Published online Apr 1, 2004. doi: 10.3748/wjg.v10.i7.991
Revised: November 10, 2003
Accepted: December 1, 2003
Published online: April 1, 2004
AIM: To evaluate the association of pre-treatment 13C-urea breath test (UBT) results with H pylori density and efficacy of eradication therapy in patients with active duodenal ulcers.
METHODS: One hundred and seventeen consecutive outpatients with active duodenal ulcer and H pylori infection were recruited. H pylori density was histologically graded according to the Sydney system. Each patient received lansoprazole (30 mg b.i.d.), clarithromycin (500 mg b.i.d.) and amoxicillin (1 g b.i.d.) for 1 week. According to pre-treatment UBT values, patients were allocated into low ( < 16‰), intermediate (16‰-35‰), and high ( > 35‰) UBT groups.
RESULTS: A significant correlation was found between pre-treatment UBT results and H pylori density (P < 0.001). H pylori eradication rates were 94.9%, 94.4% and 81.6% in the low, intermediate and high UBT groups, respectively (per protocol analysis, P = 0.11). When patients were assigned into two groups (UBT results ≤ 35‰ and > 35‰), the eradication rates were 94.7% and 81.6%, respectively (P = 0.04).
CONCLUSION: The intragastric bacterial load of H pylori can be evaluated by UBT, and high pre-treatment UBT results can predict an adverse outcome of eradication therapy.