Protective effects of tumor necrosis factor &alpha; antibody and ulinastatin on liver ischemic reperfusion in rats

doi:10.3748/wjg.v10.i21.3161

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 10, Issue 21

This Article

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (2846)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-4) series, Tables (1-2) series.

Item

Count

PDF

255

HTML

2376

Figures (1-4)

Tables (1-2)

119

Sum=2846

Nov 1, 2004 (publication date) through Apr 22, 2024

Times Cited of This Article

Times Cited (11)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Research

World J Gastroenterol. Nov 1, 2004; 10(21): 3161-3164
Published online Nov 1, 2004. doi: 10.3748/wjg.v10.i21.3161

Protective effects of tumor necrosis factor α antibody and ulinastatin on liver ischemic reperfusion in rats

Yan-Ling Yang, Ji-Peng Li, Xiao-Ping Xu, Ke-Feng Dou, Shu-Qiang Yue, Kai-Zong Li

Yan-Ling Yang, Ji-Peng Li, Ke-Feng Dou, Shu-Qiang Yue, Kai-Zong Li, Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China

Xiao-Ping Xu, Department of General Surgery, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, Guangdong Province, China

Author contributions: All authors contributed equally to the work.

Supported by the National Natural Science Foundation of China, No. 30070741

Correspondence to: Kai-Zong Li, Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China. gdwk@fmmu.edu.cn Telephone: +86-29-83375259 Fax: +86-29-83375561

Received: August 26, 2003
Revised: October 20, 2003
Accepted: October 27, 2003
Published online: November 1, 2004

Abstract

AIM: To study the protective effects of tumor necrosis factor α (TNF α ) antibody and ulinastatin on liver ischemic reperfusion in rats.

METHODS: One hundred and twenty male SD rats were randomly divided into four groups: Normal control group, ischemic group, TNFα antibody group and TNFα antibody + ulinastatin group. The animals were killed at 0, 3, 6, 9, 12 h after ischemia for 60 min and followed by reperfusion. Serum alanine aminotransferase (ALT), malondialdehyde (MDA) and liver histopathology were observed.

RESULTS: After ischemic reperfusion, the serum ALT and MDA were remarkably increased, and the hepatic congestion was obvious. Treatment of TNFα antibody and ulinastatin could significantly decrease serum ALT and MDA levels, and relieve hepatic congestion.

CONCLUSION: Ulinastatin and TNFα antibody can suppress the inflammatory reaction induced by hepatic ischemic reperfusion, and have protective effects on rat hepatic ischemic reperfusion injury.

Keywords: $[Keywords]