Brief Reports
Copyright ©The Author(s) 2004. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 15, 2004; 10(14): 2150-2152
Published online Jul 15, 2004. doi: 10.3748/wjg.v10.i14.2150
Treatment of severe Clonorchiasis sinensis by endoscopic nasobiliary drainage and oral praziquantel
Fa-Chao Zhi, Xu-Ming Liu, Ze-Quan Liu, Yan Lin, Shu-Jian Chen
Fa-Chao Zhi, PLA Institute for Digestive Medicine, Nanfang Hospital, First Military Medical University, Guangzhou 510515, Guangdong Province, China
Xu-Ming Liu, Ze-Quan Liu, Yan Lin, Shu-Jian Chen, Department of Digestive Diseases, Hexian Hospital, Panyu, Guangzhou 511400, Guangdong Province, China
Author contributions: All authors contributed equally to the work.
Correspondence to: Fa-Chao Zhi, PLA Institute for Digestive Medicine, Nanfang Hospital, First Military Medical University, Guangzhou 510515, Guangdong Province, China. zfc@fimmu.com
Telephone: +86-20-61641534 Fax: +86-20-87280770
Received: November 13, 2003
Revised: December 21, 2003
Accepted: January 12, 2004
Published online: July 15, 2004
Abstract

AIM: To assess the therapeutic value of endoscopic nasobiliary drainage (ENBD) and oral praziquantel for severe Clonorchiasis sinensis infection.

METHODS: Of the 84 Clonorchiasis sinensis-infected patients enrolled, 58 were treated with ENBD (as observing group, ENBD group), 26 received operations (control group, operation group). Both of the two groups were comparable in terms of patient’s age, body mass index. Before and one week after treatment, the average diameters of common bile ducts were measured by ultrasound, and serum bilirubin, ALP, γ-GT and ALT were detected by biochemical methods. After ENBD or operation, the patients took praziquantel for two days.

RESULTS: Compared with the patients in operation group, ENBD patients in ENBD group had higher recovery rates of abdominal pain and fever as well as jaundice, quicker remission, smaller trauma, fewer complications and lower cost.

CONCLUSION: ENBD combined with oral praziquantel is an effective and safe method for the treatment of severe Clonorchiasis sinensis.

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