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For: Lah JJ, Cui W, Hu KQ. Effects and mechanisms of silibinin on human hepatoma cell lines. World J Gastroenterol 2007; 13(40): 5299-5305 [PMID: 17879397 DOI: 10.3748/wjg.v13.i40.5299]
URL: https://www.wjgnet.com/1007-9327/full/v13/i40/5299.htm
Number Citing Articles
1
Farah Abid, Muhammad Saleem, Saleha Yasir, Shumila Arshad, Sundus Qureshi, Mayyda Asif Bajwa, Sana Ashiq, Samreen Tanveer, Mehiwh Qayyum, Kanwal Ashiq. CANCER EPIGENETICS AND THE ROLE OF DIETARY ELEMENTSGomal Journal of Medical Sciences 2020; 17(3): 96 doi: 10.46903/gjms/17.03.2070
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Jian He, Zhengxing Chen, Yao Gu, Ya'nan Li, Ren Wang, Yuan Gao, Wei Feng, Tao Wang. Hydrophilic co-assemblies of two hydrophobic biomolecules improving the bioavailability of silybinFood & Function 2020; 11(12): 10828 doi: 10.1039/D0FO01882A
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Katharina L. Hupa, Elmar Jaeckel, Michael P. Manns. Silymarin for Treatment of Nonalcoholic Steatohepatitis–A New Kid on the Block?Clinical Gastroenterology and Hepatology 2017; 15(12): 1863 doi: 10.1016/j.cgh.2017.08.005
4
G. Ramakrishnan, L. Lo Muzio, C. M. Elinos-Báez, S. Jagan, T. A. Augustine, S. Kamaraj, P. Anandakumar, T. Devaki. Silymarin inhibited proliferation and induced apoptosis in hepatic cancer cellsCell Proliferation 2009; 42(2): 229 doi: 10.1111/j.1365-2184.2008.00581.x
5
Chen-Yi Liao, Ching-Chang Lee, Chi-chang Tsai, Chao-Wen Hsueh, Chih-Chiang Wang, I-Hung Chen, Ming-Kai Tsai, Mei-Yu Liu, An-Tie Hsieh, Kuan-Jen Su, Hau-Ming Wu, Shih-Chung Huang, Yi-Chen Wang, Chien-Yao Wang, Shu-Fang Huang, Yen-Cheng Yeh, Ren-Jy Ben, Shang-Tao Chien, Chin-Wen Hsu, Wu-Hsien Kuo. Novel Investigations of Flavonoids as Chemopreventive Agents for Hepatocellular CarcinomaBioMed Research International 2015; 2015: 1 doi: 10.1155/2015/840542
6
Alisa Bahar Beydogan, Sema Bolkent. The effects of silibin administration for different time periods on mouse liver with Ehrlich ascites carcinomaPharmacological Reports 2016; 68(3): 543 doi: 10.1016/j.pharep.2015.12.003
7
Alessandro Federico, Marcello Dallio, Carmelina Loguercio. Silymarin/Silybin and Chronic Liver Disease: A Marriage of Many YearsMolecules 2017; 22(2): 191 doi: 10.3390/molecules22020191
8
Alexander Link, Francesc Balaguer, Ajay Goel. Cancer chemoprevention by dietary polyphenols: Promising role for epigeneticsBiochemical Pharmacology 2010; 80(12): 1771 doi: 10.1016/j.bcp.2010.06.036
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Elizabeth Brandon-Warner, James A. Sugg, Laura W. Schrum, Iain H. McKillop. Silibinin inhibits ethanol metabolism and ethanol-dependent cell proliferation in an in vitro model of hepatocellular carcinomaCancer Letters 2010; 291(1): 120 doi: 10.1016/j.canlet.2009.10.004
10
Gagan Deep, Rajesh Agarwal. Antimetastatic efficacy of silibinin: molecular mechanisms and therapeutic potential against cancerCancer and Metastasis Reviews 2010; 29(3): 447 doi: 10.1007/s10555-010-9237-0
11
Vlad Dionisie, Simona Clichici, Rodica M. Ion, Oana O. Danila, Remus Moldovan, Nicoleta Decea, Dan Gheban, Florin Catalin Olteanu, Gabriela A. Filip. In vivosilymarin’s antioxidant and anti-apoptotic effects on photodynamic therapy’s responsivenessJournal of Porphyrins and Phthalocyanines 2017; 21(03): 189 doi: 10.1142/S1088424617500304
12
Afrodite Betsou, Maria Lambropoulou, Anastasia-Eirini Georgakopoulou, Nikolaos Kostomitsopoulos, Ourania Konstandi, Konstantinos Anagnostopoulos, Christos Tsalikidis, Constantinos E Simopoulos, Georgia Valsami, Alexandra K Tsaroucha. The hepatoprotective effect of silibinin after hepatic ischemia/reperfusion in a rat model is confirmed by immunohistochemistry and qRT-PCRJournal of Pharmacy and Pharmacology 2021; 73(9): 1274 doi: 10.1093/jpp/rgab062
13
Shadia A. Elsayed, Shane Harrypersad, Heba A. Sahyon, Mohammed Abu El-Magd, Charles J. Walsby. Ruthenium(II)/(III) DMSO-Based Complexes of 2-Aminophenyl Benzimidazole with In Vitro and In Vivo Anticancer ActivityMolecules 2020; 25(18): 4284 doi: 10.3390/molecules25184284
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Xuanbin Wang, Ning Wang, Fan Cheung, Lixing Lao, Charlie Li, Yibin Feng. Chinese medicines for prevention and treatment of human hepatocellular carcinoma: current progress on pharmacological actions and mechanismsJournal of Integrative Medicine 2015; 13(3): 142 doi: 10.1016/S2095-4964(15)60171-6
15
Reza Ghasemi, Seyed H. Ghaffari, Majid Momeny, Saeed Pirouzpanah, Mehdi Yousefi, Mohsen Malehmir, Kamran Alimoghaddam, Ardeshir Ghavamzadeh. Multitargeting and Antimetastatic Potentials of Silibinin in Human HepG-2 and PLC/PRF/5 Hepatoma CellsNutrition and Cancer 2013; 65(4): 590 doi: 10.1080/01635581.2013.770043
16
Mahdi Mashhadi Akbar Boojar, Massoud Mashhadi Akbar Boojar, Sepide Golmohammad. Overview of Silibinin anti-tumor effectsJournal of Herbal Medicine 2020; 23: 100375 doi: 10.1016/j.hermed.2020.100375
17
S. Maya, M. Sabitha, Shantikumar V. Nair, R. Jayakumar. Multifaceted Development and Application of Biopolymers for Biology, Biomedicine and NanotechnologyAdvances in Polymer Science 2012; 254: 203 doi: 10.1007/12_2012_195
18
E Yurtcu, ÖD İşeri, FI Sahin. Genotoxic and cytotoxic effects of doxorubicin and silymarin on human hepatocellular carcinoma cellsHuman & Experimental Toxicology 2014; 33(12): 1269 doi: 10.1177/0960327114529453
19
Liang-hua Fang, Shen-lin Liu, Rui-ping Wang, Shou-you Hu, Wen-zheng Ju, Chang-yin Li. Tounong Powder (透脓散) extracts induce G1 cell cycle arrest and apoptosis in LoVo cellsChinese Journal of Integrative Medicine 2016;  doi: 10.1007/s11655-016-2597-8
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Yangyang Hu, Shengpeng Wang, Xu Wu, Jinming Zhang, Ruie Chen, Meiwan Chen, Yitao Wang. Chinese herbal medicine-derived compounds for cancer therapy: A focus on hepatocellular carcinomaJournal of Ethnopharmacology 2013; 149(3): 601 doi: 10.1016/j.jep.2013.07.030
21
Harold Ting, Gagan Deep, Rajesh Agarwal. Molecular Mechanisms of Silibinin-Mediated Cancer Chemoprevention with Major Emphasis on Prostate CancerThe AAPS Journal 2013; 15(3): 707 doi: 10.1208/s12248-013-9486-2
22
Ha Ra Gu, Su Cheol Park, Su Jin Choi, Jae Cheol Lee, You Cheoul Kim, Chul Ju Han, Jin Kim, Ki Young Yang, Yeon Joo Kim, Geum Youb Noh, So Hyeon No, Jae-Hoon Jeong. Combined treatment with silibinin and either sorafenib or gefitinib enhances their growth-inhibiting effects in hepatocellular carcinoma cellsClinical and Molecular Hepatology 2015; 21(1): 49 doi: 10.3350/cmh.2015.21.1.49
23
Erika Ramos-Tovar, Pablo Muriel. Dietary Interventions in Liver Disease2019; : 101 doi: 10.1016/B978-0-12-814466-4.00009-4
24
Vahab Ghalehkhondabi, Meysam Soleymani, Alireza Fazlali. Folate-targeted nanomicelles containing silibinin as an active drug delivery system for liver cancer therapyJournal of Drug Delivery Science and Technology 2021; 61: 102157 doi: 10.1016/j.jddst.2020.102157
25
Ajay Goel, Gaurav Chaturvedi. Nutrition, Diet and Cancer2012; : 283 doi: 10.1007/978-94-007-2923-0_13
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Jun-ichi Okano, Yuki Fujise, Ryo Abe, Ryu Imamoto, Yoshikazu Murawaki. Chemoprevention against hepatocellular carcinomaClinical Journal of Gastroenterology 2011; 4(4): 185 doi: 10.1007/s12328-011-0227-8
27
Chin-Hui Su, Li-Jen Chen, Jyh Fei Liao, Juei-Tang Cheng. Increase of Phosphatase and Tensin Homolog by Silymarin to Inhibit Human Pharynx Squamous CancerJournal of Medicinal Food 2013; 16(9): 778 doi: 10.1089/jmf.2012.2534
28
Kylie O’Brien, Avni Sali. A Clinician's Guide to Integrative Oncology2017; : 231 doi: 10.1007/978-3-319-56632-0_7
29
Yong-Hong Xu, Li-Jie Zhao, Yan Li. Alisol B acetate induces apoptosis of SGC7901 cells <italic>via</italic> mitochondrial and phosphatidylinositol 3-kinases/Akt signaling pathwaysWorld Journal of Gastroenterology 2009; 15(23): 2870-2877 doi: 10.3748/wjg.15.2870
30
Nour Y.S. Yassin, Sameh F. AbouZid, Asmaa M. El-Kalaawy, Tarek M. Ali, Mazen M. Almehmadi, Osama M. Ahmed. Silybum marianum total extract, silymarin and silibinin abate hepatocarcinogenesis and hepatocellular carcinoma growth via modulation of the HGF/c-Met, Wnt/β-catenin, and PI3K/Akt/mTOR signaling pathwaysBiomedicine & Pharmacotherapy 2022; 145: 112409 doi: 10.1016/j.biopha.2021.112409
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J. Arellanes-Robledo, C. Hernández, J. Camacho, J.I. Pérez-Carreón. Liver Pathophysiology2017; : 563 doi: 10.1016/B978-0-12-804274-8.00042-4
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Ioannis Anestopoulos, Georgia Persephoni Voulgaridou, Alexandros G. Georgakilas, Rodrigo Franco, Aglaia Pappa, Mihalis I. Panayiotidis. Epigenetic therapy as a novel approach in hepatocellular carcinomaPharmacology & Therapeutics 2015; 145: 103 doi: 10.1016/j.pharmthera.2014.09.005
33
Hong-jun Wang, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima. Inhibition of Insulin-like Growth Factor 1 Receptor Signaling Enhanced Silibinin-Induced Activation of Death Receptor and Mitochondrial Apoptotic Pathways in Human Breast Cancer MCF-7 CellsJournal of Pharmacological Sciences 2008; 107(3): 260 doi: 10.1254/jphs.08054FP
34
Mohamed El-Far, Neven Salah, Alaa Essam, Amira O Abd El-Azim, Ibrahim M El-Sherbiny. Silymarin nanoformulation as potential anticancer agent in experimental Ehrlich ascites carcinoma-bearing animalsNanomedicine 2018; 13(15): 1865 doi: 10.2217/nnm-2017-0394
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Bui Thanh Tung, Dang Kim Ngan, Do Thi Hong Khanh. Handbook of Research on Natural Products and Their Bioactive Compounds as Cancer TherapeuticsAdvances in Medical Diagnosis, Treatment, and Care 2022; : 232 doi: 10.4018/978-1-7998-9258-8.ch011
36
Wei Cui, Fan Gu, Ke-Qin Hu. Effects and mechanisms of silibinin on human hepatocellular carcinoma xenografts in nude miceWorld Journal of Gastroenterology 2009; 15(16): 1943-1950 doi: 10.3748/wjg.15.1943
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Christian Busch, Markus Burkard, Christian Leischner, Ulrich M. Lauer, Jan Frank, Sascha Venturelli. Epigenetic activities of flavonoids in the prevention and treatment of cancerClinical Epigenetics 2015; 7(1) doi: 10.1186/s13148-015-0095-z
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Cheng-Chia Tsai, Tang-Wei Chuang, Li-Jen Chen, Ho-Shan Niu, Kun-Ming Chung, Juei-Tang Cheng, Kao-Chang Lin. Increase in apoptosis by combination of metformin with silibinin in human colorectal cancer cellsWorld Journal of Gastroenterology 2015; 21(14): 4169-4177 doi: 10.3748/wjg.v21.i14.4169
39
Xing-Xing Zhu, Ya-Hui Ding, Yi Wu, Lin-Yan Qian, Hai Zou, Qiang He. Silibinin: a potential old drug for cancer therapyExpert Review of Clinical Pharmacology 2016; 9(10): 1323 doi: 10.1080/17512433.2016.1208563
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István-Péter Laszló, Mihaela Ramona Laszló, Vlad Toma, Ioana Baldea, Diana Olteanu, Luminita David, Bianca Moldovan, Rodica Mariana Ion, Remus Moldovan, Gabriela Adriana Filip, Gabriel Kacso, Calin Cainap, Simona Clichici, Adriana Muresan. The in vivo modulatory effects of Cornus mas extract on photodynamic therapy in experimental tumorsPhotodiagnosis and Photodynamic Therapy 2020; 30: 101656 doi: 10.1016/j.pdpdt.2020.101656
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Priyanka Sekar, Raashmi Ravitchandirane, Sofia Khanam, Nethaji Muniraj, Ananda Vayaravel Cassinadane. Novel molecules as the emerging trends in cancer treatment: an updateMedical Oncology 2022; 39(2) doi: 10.1007/s12032-021-01615-6
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José M. Matés. Handbook of Plant Food Phytochemicals2013; : 68 doi: 10.1002/9781118464717.ch4
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Hann-Chin Yu, Li-Jen Chen, Kai-Chun Cheng, Ying-Xiao Li, Ching-Hua Yeh, Juei-Tang Cheng. Silymarin Inhibits Cervical Cancer Cell Through an Increase of Phosphatase and Tensin HomologPhytotherapy Research 2012; 26(5): 709 doi: 10.1002/ptr.3618
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Lidia Radko, Wojciech Cybulski, Wojciech Rzeski. The Protective Effect of Silybin against Lasalocid Cytotoxic Exposure on Chicken and Rat Cell LinesBioMed Research International 2013; 2013: 1 doi: 10.1155/2013/783519
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Heike K. Winter, Veronika A. Ehrlich, Michael Grusch, Andreas Lackner, Rolf Schulte-Hermann, Bettina Grasl-Kraupp, Wolfgang Mikulits, Siegfried Knasmüller. Use of four new human-derived liver-cell lines for the detection of genotoxic compounds in the single-cell gel electrophoresis (SCGE) assayMutation Research/Genetic Toxicology and Environmental Mutagenesis 2008; 657(2): 133 doi: 10.1016/j.mrgentox.2008.08.012
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Jasmine Baby, Aswathy R. Devan, Ayana R. Kumar, Jaggaiah N. Gorantla, Bhagyalakshmi Nair, Thanatharayil Sathian Aishwarya, Lekshmi R. Nath. Cogent role of flavonoids as key orchestrators of chemoprevention of hepatocellular carcinoma: A reviewJournal of Food Biochemistry 2021; 45(7) doi: 10.1111/jfbc.13761
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P García-Maceira, J Mateo. Silibinin inhibits hypoxia-inducible factor-1α and mTOR/p70S6K/4E-BP1 signalling pathway in human cervical and hepatoma cancer cells: implications for anticancer therapyOncogene 2009; 28(3): 313 doi: 10.1038/onc.2008.398
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Ioannis Anestopoulos, Aristeidis Sfakianos, Rodrigo Franco, Katerina Chlichlia, Mihalis Panayiotidis, David Kroll, Aglaia Pappa. A Novel Role of Silibinin as a Putative Epigenetic Modulator in Human Prostate CarcinomaMolecules 2016; 22(1): 62 doi: 10.3390/molecules22010062
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Zu-Yau Lin, Wan-Long Chuang. Influence of silibinin on differential expressions of total cytokine genes in human hepatocellular carcinoma cell linesBiomedicine & Preventive Nutrition 2011; 1(2): 91 doi: 10.1016/j.bionut.2011.02.002
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Kumaraguruparan Ramasamy, Rajesh Agarwal. Multitargeted therapy of cancer by silymarinCancer Letters 2008; 269(2): 352 doi: 10.1016/j.canlet.2008.03.053
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L. Radko, W. Cybulski, W. Rzeski. Cytoprotective effect of silybin against lasalocid-induced toxicity in HepG2 cellsPolish Journal of Veterinary Sciences 2013; 16(2): 275 doi: 10.2478/pjvs-2013-0038
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Majid Momeny, Mohammad R. Khorramizadeh, Seyed H. Ghaffari, Mehdi Yousefi, Mir S. Yekaninejad, Rezvan Esmaeili, Zahra Jahanshiri, Mohammad R. Nooridaloii. Effects of silibinin on cell growth and invasive properties of a human hepatocellular carcinoma cell line, HepG-2, through inhibition of extracellular signal-regulated kinase 1/2 phosphorylationEuropean Journal of Pharmacology 2008; 591(1-3): 13 doi: 10.1016/j.ejphar.2008.06.011
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Ming-Rong Cao, Qiang Li, Zhi-Long Liu, Hui-Hui Liu, Wei Wang, Xiao-Li Liao, Yun-Long Pan, Jian-Wei Jiang. Harmine induces apoptosis in HepG2 cells via mitochondrial signaling pathwayHepatobiliary & Pancreatic Diseases International 2011; 10(6): 599 doi: 10.1016/S1499-3872(11)60102-1
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Zohreh Jahanafrooz, Nasrin Motamed, Beate Rinner, Ahad Mokhtarzadeh, Behzad Baradaran. Silibinin to improve cancer therapeutic, as an apoptotic inducer, autophagy modulator, cell cycle inhibitor, and microRNAs regulatorLife Sciences 2018; 213: 236 doi: 10.1016/j.lfs.2018.10.009
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Wen-Shiung Liou, Li-Jen Chen, Ho-Shan Niu, Ting-Ting Yang, Juei-Tang Cheng, Kao-Chang Lin. Herbal product silibinin-induced programmed cell death is enhanced by metformin in cervical cancer cells at the dose without influence on nonmalignant cellsJournal of Applied Biomedicine 2015; 13(2): 113 doi: 10.1016/j.jab.2014.11.001
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Jeanetta K. Mastron, Kodappully S. Siveen, Gautam Sethi, Anupam Bishayee. Silymarin and hepatocellular carcinomaAnti-Cancer Drugs 2015; 26(5): 475 doi: 10.1097/CAD.0000000000000211
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Lorenzo Di Cesare Mannelli, Matteo Zanardelli, Paola Failli, Carla Ghelardini. Oxaliplatin-Induced Neuropathy: Oxidative Stress as Pathological Mechanism. Protective Effect of SilibininThe Journal of Pain 2012; 13(3): 276 doi: 10.1016/j.jpain.2011.11.009
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Navaneethakrishnan Polachi, Guirong Bai, Tingyang Li, Yang Chu, Xiangyang Wang, Shuming Li, Ning Gu, Jiang Wu, Wei Li, Yanjun Zhang, Shuiping Zhou, He Sun, Changxiao Liu. Modulatory effects of silibinin in various cell signaling pathways against liver disorders and cancer – A comprehensive reviewEuropean Journal of Medicinal Chemistry 2016; 123: 577 doi: 10.1016/j.ejmech.2016.07.070
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Kai-Chun Cheng, Akihiro Asakawa, Ying-Xiao Li, Hsien-Hui Chung, Haruka Amitani, Takatoshi Ueki, Juei-Tang Cheng, Akio Inui, Marcia B. Aguila. Silymarin Induces Insulin Resistance through an Increase of Phosphatase and Tensin Homolog in Wistar RatsPLoS ONE 2014; 9(1): e84550 doi: 10.1371/journal.pone.0084550
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Yan Li, Robert C. G. Martin. Herbal Medicine and Hepatocellular Carcinoma: Applications and ChallengesEvidence-Based Complementary and Alternative Medicine 2011; 2011: 1 doi: 10.1093/ecam/neq044
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Bao-Xia Li, Heng-Bang Wang, Miao-Zhen Qiu, Qiu-Yun Luo, Han-Jie Yi, Xiang-Lei Yan, Wen-Tao Pan, Lu-Ping Yuan, Yu-Xin Zhang, Jian-Hua Xu, Lin Zhang, Da-Jun Yang. Novel smac mimetic APG-1387 elicits ovarian cancer cell killing through TNF-alpha, Ripoptosome and autophagy mediated cell death pathwayJournal of Experimental & Clinical Cancer Research 2018; 37(1) doi: 10.1186/s13046-018-0703-9
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Hayder Gaeed Oufi, Nada Naji Al-Shawi. The effects of different doses of silibinin in combination with methotrexate on testicular tissue of miceEuropean Journal of Pharmacology 2014; 730: 36 doi: 10.1016/j.ejphar.2014.02.010
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dilek bayram. Silibinin İn Vitro Ortamda CCL-228-SW 480 Kolon Kanseri Hücre Hattı Üzerine Apoptotik Etkisinin AraştırılmasıSDÜ Sağlık Bilimleri Dergisi 2017; : 1 doi: 10.22312/sdusbed.287465
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Hu Xiangbing, Zhang Yankai, Lin Ming, Lu Yong, Zhang Yu, Zhang Huiyong, Chen Yingying, Hou Jing, Xing Yun, Jin Liang, Cao Rongyue, Liu Jingjing. The fusion protein of HSP65 with tandem repeats of β-hCG acting as a potent tumor vaccine in suppressing hepatocarcinomaInternational Immunopharmacology 2010; 10(2): 230 doi: 10.1016/j.intimp.2009.11.006
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HENRIETTE KAUNTZ, SOUAD BOUSSEROUEL, FRANCINE GOSSÉ, FRANCIS RAUL. Epigenetic effects of the natural flavonolignan silibinin on colon adenocarcinoma cells and their derived metastatic cellsOncology Letters 2013; 5(4): 1273 doi: 10.3892/ol.2013.1190