New era of epidermal growth factor receptor-tyrosine kinase inhibitors for lung cancer

doi:10.5320/wjr.v6.i2.57

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Jul 28, 2016 (publication date) through Apr 15, 2024

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World Journal of Respirology

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2218-6255

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Respirol. Jul 28, 2016; 6(2): 57-62
Published online Jul 28, 2016. doi: 10.5320/wjr.v6.i2.57

Table 3 Phase I clinical studies of third generation epidermal growth factor receptor- tyrosine kinase inhibitors[26-28]

Study and ref.	n	EGFR mutations	ORR (%)	ORR in EGFRT790M (%)	ORR in non EGFRT790M (%)
AZD9291[26]	232	exon 19del	53	64	22
		L858R
		T790M
CO-1686[27]	72	exon 19del	NA	58	NA
		L858R
		T790M
HM61713[28]	83	T790M	21.7	29.2	NA

EGFR: Epidermal growth factor receptor; NA: Not available.

Citation: Macedo JE. New era of epidermal growth factor receptor-tyrosine kinase inhibitors for lung cancer. World J Respirol 2016; 6(2): 57-62
URL: https://www.wjgnet.com/2218-6255/full/v6/i2/57.htm
DOI: https://dx.doi.org/10.5320/wjr.v6.i2.57