Differential role of Hedgehog signaling in human pancreatic (patho-) physiology: An up to date review

doi:10.4291/wjgp.v7.i2.199

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World Journal of Gastrointestinal Pathophysiology

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2150-5330

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Pathophysiol. May 15, 2016; 7(2): 199-210
Published online May 15, 2016. doi: 10.4291/wjgp.v7.i2.199

Table 2 Clinical trials of Hedgehog inhibitors for pancreatic cancer (https://clinicaltrials.gov/)

Drug	Combination	Phase	Status	Trial ID
GDC-0449	Gemcitabine	0	N	NCT01713218
		1/2	A	NCT01195415
		2	A	NCT01064622
	Erlotinib, gemcitabine	1	A	NCT00878163
	Gemcitabine, nab-paclitaxel	2	A	NCT01088815
LDE-225	Gemcitabine, nab-paclitaxel	1/2	R	NCT01431794
		1/2	R	NCT02358161
	BKM120	1	C	NCT01576666
IPI-926	Gemcitabine	1/2	C	NCT01130142

A: Active, not recruiting; C: Completed; N: Not yet recruiting; R: Recruiting.

Citation: Klieser E, Swierczynski S, Mayr C, Jäger T, Schmidt J, Neureiter D, Kiesslich T, Illig R. Differential role of Hedgehog signaling in human pancreatic (patho-) physiology: An up to date review. World J Gastrointest Pathophysiol 2016; 7(2): 199-210
URL: https://www.wjgnet.com/2150-5330/full/v7/i2/199.htm
DOI: https://dx.doi.org/10.4291/wjgp.v7.i2.199