BLEED-Myocardial Infarction Score: Predicting mid-term post-discharge bleeding events

Table 2 Calculation of the BLEED-myocardial infarction score

Variable	Points assigned
Age (yr)
< 65	0
65-74	1
≥ 75	2
GFR at admission (MDRD formula, mL/min)
≥ 60	0
30-59.9	1
< 30	2
History of stroke or transient ischemic attack1
No	0
Yes	1
Heart failure during hospitalization2
No	0
Yes	1
History of hypertension
No	0
Yes	1
Antithrombotic therapy3
1 agent	1
2 agents	2
3 agents	3
Hemoglobin at admission (g/dL)
≥ 12	0
10-11.9	1
< 10	2
Blood urea nitrogen at admission (mg/dL)
< 10	0
10-25	1
> 25	2
History of major hemorrhage or bleeding event during hospitalization4
No	0
Yes	1
Smoking habits (until hospitalization)
No	0
Yes	1
History of diabetes mellitus
No	0
Yes	1

The BLEED-myocardial infarction (MI) score is obtained by summing all the points assigned for each predictor.

¹Previous neurologic events were defined as history of sudden onset of a focal neurologic deficit in a location consistent with the territory of a major cerebral artery or the radiological documentation of previous cerebral infarction (irrespective of the presence/absence of symptoms);

²Heart failure was defined as a maximum Killip Class > 1 at any time during hospitalization. Therefore, it includes both patients with previous history of heart failure and those with de novo heart failure during hospitalization;

³Including anti-platelet agents (such as Acetylsalicylic Acid and Clopidogrel) and/or anticoagulants (such as Warfarin). At the time patients assigned to the derivation sample were admitted to our Acute Cardiac Care Unit, agents such as Prasugrel, Ticagrelor or Dabigatran were not available;

⁴History of major hemorrhage defined as previous non-fatal hemorrhagic stroke or history of serious bleeding requiring transfusion. Bleeding event during hospitalization represents the occurrence of a hemorrhagic episode during hospitalization for the MI index, as described for the primary endpoint, plus any significant bleeding event attributable to revascularization procedures (again, as described for the primary endpoint). GFR: Glomerular filtration rate.