BLEED-Myocardial Infarction Score: Predicting mid-term post-discharge bleeding events

Core Tip

Core tip: Prediction of mid- to long-term clinically significant bleeding following discharge for a myocardial infarction has received scarce attention from the scientific community. The BLEED-myocardial infarction (MI) prediction model is the first score designed to predict mid-term hemorrhagic risk in these patients. Easy to use and comprising clinical and analytical items that can be collected in a few minutes, BLEED-MI showed good calibration, accuracy and discriminative performance for predicting post-discharge hemorrhagic episodes and a composite endpoint of bleeding events plus all-cause mortality. Importantly, an accurate prediction of bleeding events was shown independently of mortality. Furthermore, a progressively increasing risk of the primary and secondary endpoints was seen with increasing BLEED-MI scores and our results suggested a very high capability of the BLEED-MI rule in identifying low-risk patients. Depending on its potential external validation in larger cohorts of patients, the BLEED-MI score may eventually help tailor therapeutic decisions