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World J Cardiol. Jun 26, 2014; 6(6): 376-380
Published online Jun 26, 2014. doi: 10.4330/wjc.v6.i6.376
Published online Jun 26, 2014. doi: 10.4330/wjc.v6.i6.376
Effect of genetic factors on the association between coronary artery disease and PTPN22 polymorphism
Fulvia Gloria-Bottini, Patrizia Saccucci, Egidio Bottini, Department of Biomedicine and Prevention, School of Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
Maria Banci, Department of Cardiology, Valmontone Hospital, 00038 Valmontone, Italy
Paolo Nardi, Mattia Scognamiglio, Antonio Pellegrino, Luigi Chiariello, Department of Cardiac Surgery, University of Rome Tor Vergata, School of Medicine, 00133 Rome, Italy
Author contributions: Gloria-Bottini F, Pellegrino A, Bottini E and Chiariello L contributed equally to the ideation of this research and wrote the paper; Saccucci P, Banci M, Nardi P and Scognamiglio M contributed to the data collection and statistical analysis; all authors contributed to the final revision of the paper.
Correspondence to: Fulvia Gloria-Bottini, MD, Department of Biomedicine and Prevention, School of Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy. gloria@med.uniroma2.it
Telephone: +39-6-30889514 Fax: +39-6-30889514
Received: December 12, 2013
Revised: January 16, 2014
Accepted: May 8, 2014
Published online: June 26, 2014
Revised: January 16, 2014
Accepted: May 8, 2014
Published online: June 26, 2014
Core Tip
Core tip: Acid phosphatse locus 1, p53 codon 72 and adenosine deaminase have an important role in immune reactions and influence the strength of association between coronary artery disease (CAD) and PTPN22 an enzyme involved in autoimmunity. These results agree with multifactorial origin of CAD.