Does the discrepancy in histologic differentiation between a forceps biopsy and an endoscopic specimen necessitate additional surgery in early gastric cancer?

Table 4 Comparison of histopathological characteristics between 23 specimens having discrepancy and 103 specimens having non-discrepancy along with undifferentiated postoperative histology n (%)

Variables	Discrepancy	Non-discrepancy	P value
Tumor size in the specimen (n = 126)
Median, cm (range)	3.0 (0.8-5.5)	2.5 (0.5-8.0)	0.343
Number of biopsies (n = 126)
Median, No. (range)	3 (2-6)	3 (1-8)	0.374
Location (n = 126)
Upper	3 (13.0)	10 (9.7)	0.481
Middle	10 (43.5)	62 (60.2)
Lower	10 (43.5)	31 (30.1)
Gross pattern (n = 126)
Elevated	1 (4.3)	1 (1.0)	0.615
Flat	4 (17.4)	20 (19.4)
Depressed	9 (39.1)	51 (49.5)
Mixed elevated	2 (8.7)	6 (5.8)
Mixed flat	4 (17.4)	16 (15.5)
Mixed depressed	3 (13.0)	9 (8.7)
Tumor staging (n = 126)
Ia	6 (26.1)	52 (50.5)	0.034
Ib	17 (73.9)	51 (49.5)
Nodal staging (n = 126)
Positive	6 (26.1)	9 (8.7)	0.020
Negative	17 (73.9)	94 (91.3)
Lymphatic invasion (n = 126)
Positive	7 (30.4)	12 (11.7)	0.023
Negative	16 (69.6)	91 (88.3)
Vascular invasion (n = 126)
Positive	2 (8.7)	2 (1.9)	0.152
Negative	21 (91.3)	101 (98.1)
Ki-67 (n=120)
High	48 (94.7)	77 (76.2)	0.119
Low	1 (5.3)	24 (23.8)
p53 (n = 120)
Positive	13 (68.4)	59 (58.4)	0.414
Negative	6 (31.6)	42 (41.6)
HER2 (n = 120)
Positive (2+ and 3+)	7 (36.8)	16 (15.8)	0.033
Negative (0 and 1+)	12 (63.2)	85 (84.2)
EGFR (n = 120)
Positive	16 (84.2)	52 (51.5)	0.011
Negative	3 (15.8)	49 (48.5)

HER2: Human epidermal growth factor 2; EGFR: Epidermal growth factor receptor.