Core fucosylation and its roles in gastrointestinal glycoimmunology

Figure 2 Programmed cell death 1 core fucosylation in tumorigenesis. Loss of core fucosylation catalyzed by fucosyltransferase 8 significantly enhanced CD8⁺ cytotoxic T cell activation and cytotoxicity by increasing programmed cell death 1 (PD-1) ubiquitination which in turn led to the degradation of PD-1 in the proteasome and more efficient. PD-1: Programmed cell death 1; PD-L1: Programmed cell death 1 ligand 1; Fut8: Fucosyltransferase 8; CTL: Cytotoxic T cell. This figure was summarized and modified from Zhang et al[33].