Review
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jul 15, 2023; 15(7): 1119-1134
Published online Jul 15, 2023. doi: 10.4251/wjgo.v15.i7.1119
Core fucosylation and its roles in gastrointestinal glycoimmunology
Nian-Zhu Zhang, Li-Fen Zhao, Qian Zhang, Hui Fang, Wan-Li Song, Wen-Zhe Li, Yu-Song Ge, Peng Gao
Nian-Zhu Zhang, Li-Fen Zhao, Peng Gao, Clinical Laboratory, The Second Hospital of Dalian Medical University, Dalian 116023, Liaoning Province, China
Qian Zhang, Department of Cell Therapy, Shanghai Tianze Yuntai Biomedical Co., Ltd., Shanghai 200100, China
Hui Fang, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba 305-0005, Ibaraki, Japan
Wan-Li Song, Wen-Zhe Li, Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Shantou University Medical College, Shantou 515041, Guangdong Province, China
Yu-Song Ge, Department of Neurology, The Second Hospital of Dalian Medical University, Dalian 116023, Liaoning Province, China
Author contributions: Zhang NZ and Zhao LF contributed equally to this work and wrote the manuscript; Gao P revised the review; Li WZ and Ge YS designed the structure of review; Zhang Q, Fang H, and Song WL prepared the figures and table; all authors have read and approve the final manuscript.
Supported by the National Natural Science Foundation of China, No. 32171279; Natural Science Foundation of Liaoning Province, No. 2022-BS-254, and No. 2022-MS-317; and the Project of Dalian Medical Science Research, No. 2012026.
Conflict-of-interest statement: The authors declare no commercial or financial conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Peng Gao, MD, PhD, Director, Professor, Clinical Laboratory, The Second Hospital of Dalian Medical University, No. 467 Zhongshan Road, Shahekou District, Dalian 116023, Liaoning Province, China. gaop@dicp.ac.cn
Received: January 18, 2023
Peer-review started: January 18, 2023
First decision: February 24, 2023
Revised: February 28, 2023
Accepted: May 8, 2023
Article in press: May 8, 2023
Published online: July 15, 2023
Core Tip

Core Tip: Core fucosylation is driven by fucosyltransferase 8 (Fut8), which catalyzes the addition of α-1,6-fucose to the innermost GlcNAc residue of N-glycans. Core fucosylation plays a vital role in immune responses. Most immune system molecules are core fucosylated glycoproteins that play important roles in antigen recognition and clearance, cell adhesion, lymphocyte activation, apoptosis, signal transduction, and endocytosis. Fut8 is involved in humoral immune responses, cellular immunity, mucosal immunity, and tumor immunology. Here, we summarize the roles and potential modulatory mechanisms of Fut8 in various immune responses of the gastrointestinal system.