Evidence-Based Medicine
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jul 15, 2023; 15(7): 1295-1310
Published online Jul 15, 2023. doi: 10.4251/wjgo.v15.i7.1295
Comprehensive bioinformatic analysis of mind bomb 1 gene in stomach adenocarcinoma
Di Wang, Qi-Hong Wang, Ting Luo, Wen Jia, Jing Wang
Di Wang, Qi-Hong Wang, Ting Luo, Wen Jia, Jing Wang, Department of Digestive Endoscopy, The General Hospital of Northern Theater Command, Shenyang 110840, Liaoning Province, China
Di Wang, Qi-Hong Wang, Ting Luo, Postgraduate College, China Medical University, Shenyang 110840, Liaoning Province, China
Author contributions: Wang J contributed to conceptualization; Wang D wrote the paper; Wang QH, Luo T, and Jia W collected and analyzed data.
Supported by the Science and Technology Program of Liaoning Province, No. 2021-MS-040.
Conflict-of-interest statement: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
PRISMA 2009 Checklist statement: We have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jing Wang, MS, Deputy Director, Department of Digestive Endoscopy, The General Hospital of Northern Theater Command, No. 83 Wenhua Road, Shenhe District, Shenyang 110840, Liaoning Province, China. 13309882063@163.com
Received: February 27, 2023
Peer-review started: February 27, 2023
First decision: March 14, 2023
Revised: March 27, 2023
Accepted: May 8, 2023
Article in press: May 8, 2023
Published online: July 15, 2023
ARTICLE HIGHLIGHTS
Research background

Gastric cancer (GC) is a disease with multi-etiology and multi-pathway involvement, and it is characterized by a low 5-year survival rate. NOTCH signaling pathway is also involved in the occurrence and development of GC. Mind bomb 1 (MIB1), an E3 ubiquitin ligase, plays a central role in activating the NOTCH pathway by mediating ubiquitination of NOTCH ligand. However, the effect of MIB1 on GC has not been reported.

Research motivation

To investigate the effect of MIB1 gene on the prognosis of GC.

Research objectives

To investigate the effect of expression and mutation of MIB1 gene on the prognosis of GC, the function of MIB1 in GC and its relationship with immune infiltration.

Research methods

TCGA database, cBioPortal database, a receiver operating characteristic (ROC) curve, Kaplan-Meier plotter, LinkedOmics database, STRING database, The Gene Ontology enrichment , Kyoto Encyclopedia of Genes and Genomes pathway and TIMER database were used in this study.

Research results

The level of MIB1 expression had a certain impact on the survival rate of patients with GC. The prognosis of patients with high MIB1 was worse than that of patients with low MIB1. The increased expression of MIB1 gene was associated with high TNM staging, suggesting that MIB1 may play a role in the development of GC. The expression of MIB1 gene was associated with immune infiltration.

Research conclusions

The up-regulation of MIB1 expression was significantly related to the low survival rate and immune infiltration in gastric adenocarcinoma.

Research perspectives

MIB1 may be a biomarker for poor prognosis of gastric adenocarcinoma and a potential immunotherapeutic target.