Retrospective Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Mar 27, 2023; 15(3): 431-440
Published online Mar 27, 2023. doi: 10.4254/wjh.v15.i3.431
Coexistent alcohol-related cirrhosis and chronic pancreatitis have a comparable phenotype to either disease alone: A comparative retrospective analysis
Michael Lu, Yujie Sun, Robert Feldman, Melissa Saul, Andrew Althouse, Gavin Arteel, Dhiraj Yadav
Michael Lu, Yujie Sun, Melissa Saul, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, United States
Robert Feldman, Andrew Althouse, Department of Medicine, Center for Research on Health Care Data, Pittsburgh, PA 15213, United States
Gavin Arteel, Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, United States
Dhiraj Yadav, Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, United States
Author contributions: Yadav D designed the research, contributed to the analysis and wrote the paper; Lu M, Sun Y performed the research, contributed to the analysis and wrote the paper; Arteel G contributed to the design of the study and provided clinical advice; Saul M retrieved patient information from UPMC databases, Feldman R, Althouse A performed the research and statistical analysis. All authors reviewed and approved the final version of the manuscript.
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board of the University of Pittsburgh (STUDY 20100015).
Informed consent statement: We obtained a waiver of informed consent since the research represents no more than minimal risk of harm to subjects and involves no procedures for which written consent is normally required outside of the research context.
Conflict-of-interest statement: All the authors declare that they have no conflict of interest.
Data sharing statement: The dataset for this study is available from the corresponding author on reasonable request and fulfilment of regulatory requirements.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dhiraj Yadav, MD, Full Professor, Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, 200 Lothrop Street, M2, C-Wing, Pittsburgh, PA 15213, United States. yadavd@upmc.edu
Received: December 7, 2022
Peer-review started: December 7, 2022
First decision: December 19, 2022
Revised: February 3, 2023
Accepted: March 9, 2023
Article in press: March 9, 2023
Published online: March 27, 2023
Core Tip

Core Tip: Patients with coexistent alcohol-related cirrhosis and alcohol-related chronic pancreatitis do not have a worse phenotype when compared with single organ disease patients. The dominant phenotype in patients with coexistent disease (CD) in terms of overall survival and markers of advanced liver disease was similar to patients with Alcohol-related Cirrhosis Only. Coexistent disease patients also had lower prevalence of disease-related manifestations when compared with those who had single organ disease. Patients with CD may not need to be monitored at a higher degree, but the primary focus for longitudinal follow-up should be on alcohol-related cirrhosis.