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World J Stem Cells. Aug 26, 2022; 14(8): 587-598
Published online Aug 26, 2022. doi: 10.4252/wjsc.v14.i8.587
Metabolic determinants of stemness in medulloblastoma
Paula Martín-Rubio, Pilar Espiau-Romera, Alba Royo-García, Laia Caja, Patricia Sancho
Paula Martín-Rubio, Pilar Espiau-Romera, Alba Royo-García, Patricia Sancho, Hospital Universitario Miguel Servet, IIS Aragón, Zaragoza 50009, Spain
Laia Caja, Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala University, Uppsala SE-751, Sweden
Author contributions: Martín-Rubio P, Espiau-Romera P, Royo García A, Caja L, and Sancho P drafted the manuscript; Caja L and Sancho P designed the study and wrote the final version of the manuscript; Martín-Rubio P designed the figures; All authors approved the final version of the manuscript.
Supported by the Miguel Servet and pFIS fellowships, No. CP16/00121 (P.S.) and No. FI21/00031 (P.E-R.) from the Instituto de Salud Carlos III and cofinanced by European funds (FSE: “el FSE invierte en tu futuro”); Magnus Bergvalls Stiftelse, No. 2021-04284 (L.C.); and the IV Grant for Childhood Cancer Research from Asociación de Padres de Niños con Cáncer de Aragón (ASPANOA, P.S.).
Conflict-of-interest statement: There are no conflicts of interest to report.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Patricia Sancho, PhD, Senior Researcher, Hospital Universitario Miguel Servet, IIS Aragón, 1-3 Avda Isabel la Católica, Zaragoza 50009, Spain. psancho@iisaragon.es
Received: April 7, 2022
Peer-review started: April 7, 2022
First decision: May 11, 2022
Revised: May 26, 2022
Accepted: July 31, 2022
Article in press: July 31, 2022
Published online: August 26, 2022
Core Tip

Core Tip: Considering the profound cellular metabolism rewiring associated with the tumorigenesis process, metabolic targeting for cancer treatment has gained a lot of attention in the last years. Interestingly, increasing evidence indicates that cancer stem cells (CSCs) show unique metabolic features within tumours. A deeper understanding of the metabolic vulnerabilities of medulloblastoma (MB) and MB-CSCs would accelerate the design of novel therapeutic strategies with the aim of improving the survival of paediatric patients suffering this disease.