Intramuscular vs intradermal route for hepatitis B booster vaccine in celiac children

doi:10.3748/wjg.v18.i40.5729

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Oct 28, 2012 (publication date) through May 6, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 28, 2012; 18(40): 5729-5733
Published online Oct 28, 2012. doi: 10.3748/wjg.v18.i40.5729

Table 1 Comparison of age, gender, duration of illness and gluten intake in patients receiving vaccine booster by the intradermal or intramuscular route

	Intradermal	Intramuscular	P value
Age (yr)	10.45 ± 6.7¹	9.3 ± 5.9¹	NS²
Gender (male/female)	10/20	9/19	NS³
Duration of illness (yr)	6.15 ± 4.1¹	7.5 ± 4.6¹	NS²
Gluten Intake (yr)	5.3 ± 3.7¹	4.6 ± 3.2¹	NS²

NS: Not significant.

¹mean ± SD;

²Mann-Whitney U-test;

³Fisher exact test.

Table 2 Number and percentage of responders to the different booster doses and comparison of anti-hepatitis B surface titer after the first and the third doses

Booster doses	Intradermal		Intramuscular		P value
	Responders	Anti-HBs titer	Responders	Anti-HBs titer
First	23/30 (76.7)	433.35 ± 476.76	22/28 (78.6)	280.4 ± 328.97	NS¹
Second	4/30 (13.3)		5/28 (17.8)		NS²
Third	0/30 (0)	459 ± 455.87	0/28 (0)	294 ± 320.8	NS¹
Total	27/30 (90)		27/28 (96.4)		NS²

Data are presented as mean ± SD or n (%).

¹Fisher exact test (intradermal vs intramuscular responders) and Mann-Whitney U-test (antibodies titer comparison);

²Fisher exact test (intradermal vs intramuscular responders). NS: Not significant; HBs: Hepatitis B surface.

Citation: Leonardi S, Praticò AD, Lionetti E, Spina M, Vitaliti G, Rosa ML. Intramuscular vs intradermal route for hepatitis B booster vaccine in celiac children. World J Gastroenterol 2012; 18(40): 5729-5733
URL: https://www.wjgnet.com/1007-9327/full/v18/i40/5729.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i40.5729