Serum metabolomic characteristics and their predictive value for ninety-day prognosis in patients with acute-on-chronic liver failure

Figure 1 Principal component analysis, orthogonal partial least squares-discriminant analysis, and variable importance in projection distribution between the groups. A: Volcano plot of metabolite distribution, where each point represents one metabolite; B: Principal component analysis of metabolite distribution, where each point represents one sample; C: Orthogonal partial least squares-discriminant analysis of metabolite distribution, where each point represents one sample; D: Variable importance in projection diagram from orthogonal partial least squares-discriminant analysis (variable importance in projection > 1 indicates significant variables); E: Venn diagram of differential metabolites, showing seven shared metabolites from univariate and multivariate analyses (death vs survival groups). Ala: Alanine; Arg: Arginine; Pro: Proline; C18:1: Oleic acid; IIe: Isoleucine; Leu: Leucine; Val: Valine; Gly: Glycine; CDCA: Chenodeoxycholic acid; Thr: Threonine; Asp: Aspartate; Ser: Serine; Lys: Lysine; Tyr: Tyrosine; Glu: Glutamate; Gln: Glutamine.