Application of nanotechnology in reversing therapeutic resistance and controlling metastasis of colorectal cancer

Figure 4 Organosilica-based O₂ nanoeconomizer improved radiotherapy efficacy. A: Design and synthesis of nanoeconomizer; B: pHPFON-NO reduced oxygen consumption (left), and broadened oxygenation (right); C: Multi-modal imaging by pHPFON-NO/O₂, and inhibited tumor growth after pHPFON-NO/O₂ administration. Citation: Tang W, Yang Z, He L, Deng L, Fathi P, Zhu S, Li L, Shen B, Wang Z, Jacobson O, Song J, Zou J, Hu P, Wang M, Mu J, Cheng Y, Ma Y, Tang L, Fan W, Chen X. A hybrid semiconducting organosilica-based O(2) nanoeconomizer for on-demand synergistic photothermally boosted radiotherapy. Nat Commun 2021; 12: 523[245]. Copyright ©The Author(s) 2021. Published by Springer Nature Ltd. The authors have obtained the permission for figure using from the Springer Nature Ltd. (Supplementary material).