Transcription factors specificity protein and nuclear receptor 4A1 in pancreatic cancer

Figure 2 Genomic analysis of Sp1, Sp3 and Sp4 regulated genes in pancreatic cancer cells. A: The number of total genes regulated by specificity protein (Sp) transcription factors (TFs) in Panc1 cell was determined by individual Sp knockdown (siSp1, siSp3 and siSp4) and the number of unique (Different genes) and commonly repressed (Genes commonly repressed) and induced (Genes commonly induced) genes are indicated; B-D: Ingenuity Pathway Analysis analysis of genes that regulate cell proliferation (B), cell death (C) and migration/invasion (D) compares the number of unique and commonly repressed/induced genes by Sp1 and Sp3, Sp1 and Sp4 and Sp3 and Sp4 as described[66].