Retrospective Study
Copyright ©The Author(s) 2021.
World J Gastroenterol. Sep 14, 2021; 27(34): 5753-5763
Published online Sep 14, 2021. doi: 10.3748/wjg.v27.i34.5753
Table 1 An overview of formulas and cutoffs for determining non-invasive marker panels for detection of liver fibrosis[10-12,21,22]
Formula
Equation
Lower cutoff
Higher cutoff
FIB-4[Age (yr) × AST (IU/L)]/{platelet count (109/L) × [ALT(IU/L)]1/2}1.32.67[11]
1.453.25[22]
APRI[(AST/ULN)/platelet count (109/L)] × 1000.51.5[21]
NFS-1.675 + 0.037 × age (yr) + 0.094 × BMI (kg/m2) + 1.13 × IFG/diabetes (yes = 1, no = 0) + 0.99 × AST/ALT-0.013 × platelet count (× 109/L) - 0.66 × albumin (g/dL)-0.6761.455[10]
BARDScale 0-4; BMI ≥ 28 kg/m2 = 1 point; AST/ALT ≥ 0.8 = 2 points; Diabetes = 1 point2[12]
ALT: Alanine aminotransferase; APRI: Aspartate aminotransferase to platelet ratio index; AST: Aspartate aminotransferase; BARD: Body mass index, aspartate aminotransferase/alanine aminotransferase ratio, diabetes score; BMI: Body mass index; FIB-4: Fibrosis-4 index; IFG: Impaired fasting glucose; NFS: Nonalcoholic fatty liver disease fibrosis score; ULN: Upper limit of normal.