Serum outperforms plasma in small extracellular vesicle microRNA biomarker studies of adenocarcinoma of the esophagus

Figure 2 Comparison of the microRNA content between serum and plasma small extracellular vesicles. A: The number of total detectable microRNA (miRNAs) (top Venn diagram), and the number of miRNAs detected in all serum or plasma samples (bottom Venn diagram), were higher in plasma; B: Pairwise comparison of the number of total detectable miRNAs was significantly higher in the plasma (Wilcoxon signed-rank test, ^bP = 0.005); C: Correlation of the average relative expression of the 372 common total detectable miRNAs (Spearman’s R = 0.87, ^cP < 0.001); D: Correlation of the average relative expression of the 118 common miRNAs detected in all serum or plasma samples (Spearman’s R = 0.92, ^cP < 0.001). miRNA: MicroRNA.