Identification of differentially expressed genes regulated by methylation in colon cancer based on bioinformatics analysis

Figure 1 Differentially expressed genes and differentially methylated genes identified from The Cancer Genome Atlas project database. A: Volcano plot of differentially expressed genes between colon cancer and normal tissues [log₂ fold change (FC) > 2, P < 0.01]. Red dots represent up-regulated genes and green dots represent down-regulated genes. Black dots represent the genes with a fold-change in expression of <2; B: Heat map of the top 50 differentially methylated genes (DMGs) (log₂ FC > 1, P < 0.01). The left vertical axis shows clusters of DMGs and right vertical axis represents gene names. Red represents hypermethylated genes and green represents hypomethylated genes. DMGs: Differentially methylated genes; FC: Fold change.