Altered oral microbiota in chronic hepatitis B patients with different tongue coatings

doi:10.3748/wjg.v24.i30.3448

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 14, 2018; 24(30): 3448-3461
Published online Aug 14, 2018. doi: 10.3748/wjg.v24.i30.3448

Table 1 Physiological characteristics of the subjects

	Healthy	CHB patients		P value
	Healthy	White tongue coating	Yellow tongue coating	P value
Age	34.09 ± 7.16	34.46 ± 9.92	38.08 ± 9.89	0.255
Gender, male/female	13/9	21/7	17/8	0.488
BMI (kg/m²)	21.22 (16.61-25.56)	23.44 (18.42-31.64)	23.30 (18.37-45.67)	0.077
Antiviral drugs (%)	/	78.60%	64%	0.24
Chinese herbs (%)	/	17.90%	28%	0.378
TBIL (μmol/L)	14.87 (8.29-31.62)	12.85 (7.9-27.7)	17.27 (6.4-45.6)	0.27
DBIL (μmol/L)	3.065 (1.7-6.76)	3.9 (1.64-9.2)	4.8 (2.05-34.7)^b	0.006
IDBIL (μmol/L)	11.6 (6.3-25.7)	8.95 (5-18.7)	10.2 (4.2-19.6)	0.282
ALT (IU/L)	15 (10-34)	28.75 (8.5-170)^b	47 (11.1-533)^c	< 0.001
AST (IU/L)	17.5 (11-31)	27 (12-133)^b	38 (14.8-543)^c	< 0.001
ALP(IU/L)	15.28 (9-52)	25.8 (10.01-98)	38 (8.6-274)^c	< 0.001
GGT (IU/L)	70.5 (35-119)	72.7 (37.1-131)	76.3 (41.7-202)	0.62
ALB (g/L)	44.97 (40.89-50.77)	48.7 (43.1-56.3)^a^d	46 (36.6-50.1)	0.003
PT (s)	12.55 (11.3-13.9)	12.7 (11.1-16.4)	13.3 (11.3-16)	0.032
HBV-DNA (IU/mL)	/	500 (500-44830000)^d	21210 (500-324100000)	0.03
BUN (mmol/L)	4.39 (2.97-6.39)	4.96 (2.96-8.9)	4.2 (2.4-7.28)	0.074
Gr (μmol/L)	72.355 (45.1-106.67)	70 (27.4-96.7)	69 (35.9-83)	0.449
UN (μmol/L)	305.5 (201-406)	325 (207-550)	294 (154-429)	0.204
FPG (mmol/L)	5.2 (3.96-5.63)	5.2 (4.29-7.09)	5.215 (4.07-15.54)	0.532
TC (mmol/L)	4.04 (0.37-6.34)	4.55 (3.15-6.52)	4.36 (3.1-6.74)	0.102
TG (mmol/L)	0.84 (0.37-1.91)	1.17 (0.58-3.31)^a	1.11 (0.68-2.62)^a	0.008
HDL (mmol/L)	1.14 (0.74-1.76)	1.145 (0.72-1.86)	1.07 (0.58-2.02)	0.779
LDL (mmol/L)	2.205 (1.38-5.04)	2.27 (1.47-3.8)	2.44 (1.12-3.73)	0.647
APOA-A (g/L)	1.175 (0.85-1.62)	1.08 (0.76-1.91)^c	1.02 (0.71-1.42)^c	0.013

Quantitative results are expressed as median with minimum and maximum into brackets. The P values indicate the significance of difference among groups, and the Kruskal-Wallis test for 3 groups and Nemenyi test were used for post pairwise comparisons. The HBV-DNA titers between the chronic hepatitis B (CHB) yellow and white tongue coating patients were compared using the standard non-parametric Mann-Whitney U test. The antiviral drugs usage and the Chinese herbs usage were compared between CHB yellow and white tongue coating patients using the Chi-square test.

^aP < 0.05 vs healthy controls,

^bP < 0.01 vs healthy controls,

^cP < 0.001 vs healthy controls,

^dP < 0.05 vs CHB yellow tongue coating patients.

Citation: Zhao Y, Mao YF, Tang YS, Ni MZ, Liu QH, Wang Y, Feng Q, Peng JH, Hu YY. Altered oral microbiota in chronic hepatitis B patients with different tongue coatings. World J Gastroenterol 2018; 24(30): 3448-3461
URL: https://www.wjgnet.com/1007-9327/full/v24/i30/3448.htm
DOI: https://dx.doi.org/10.3748/wjg.v24.i30.3448