Liver intravoxel incoherent motion diffusion-weighted imaging for the assessment of hepatic steatosis and fibrosis in children

doi:10.3748/wjg.v24.i27.3013

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 21, 2018; 24(27): 3013-3020
Published online Jul 21, 2018. doi: 10.3748/wjg.v24.i27.3013

Table 2 Comparison of clinical and magnetic resonance imaging findings between the three groups

		Normal (n = 8)¹	FAT (n = 93)¹	FIB (n = 22)¹	P-value²	P-value³	P-value⁴	P-value⁵
Clinical findings	Age (yr)	11 (9.25-13.75)	12 (10-15.5)	10 (8.75-11)	< 0.001^a	0.611	0.855	< 0.001^a
	Gender (M:F)	4:04	70:23:00	9:13	0.005^a	0.615	1.000	0.012^a
	Weight (kg)	36.5 (28.5-49.5)	65 (51.9-76.5)	33 (28.3-44)	< 0.001^a	0.001^a	1.000	< 0.001^a
	Height (cm)	145 (137-162)	158 (145-164)	136.3 (131.8-148.1)	< 0.001^a	0.543	0.563	< 0.001^a
	AST (IU/L)	22.5 (18.3-24.8)	52.0 (27.0-80.5)	33.0 (22.8-68.0)	0.007^a	0.008^a	0.167	0.541
	ALT (IU/L)	11.0 (9.0-12.0)	87.0 (44.5-138.5)	28.0 (16.0-55.3)	< 0.001^a	< 0.001^a	0.533	< 0.001^a
MRI findings	PDFF (%)	2.65 (2.4-3.1)	22 (14.1-34)	2.6 (2.0-4.1)	< 0.001^a	< 0.001^a	1.000	< 0.001^a
	T2* (millisecond)	25.8 (22.0-27.3)	18 (16.1-20.75)	23.4 (21-26.6)	< 0.001^a	0.007^a	1.000	< 0.001^a
	MRE (kPa)⁶	2.0 (1.6-2.5)	2.6 (2.2-3.1)	3.2 (2.8-4.6)	< 0.001^a	0.058	< 0.001^a	0.001^a
	D (× 10^-3 mm²/s)	1.06 (1.03, 1.1)	1.07 (0.94, 1.35)	0.93 (0.81, 1.2)	0.158
	D* (× 10^-3 mm²/s)	70.2 (44.3, 139.7)	61 (39.5, 81.2)	36.5 (19.2, 52.5)	0.001^a	0.937	0.015^a	0.003^a
	f (%)	28.5 (18.6, 34.8)	31.5 (27.9, 39.3)	19.3 (14.0, 33.2)	0.001^a	0.542	1.000	< 0.001^a
	ADC (× 10^-3 mm²/s)	1.08 (0.97, 1.2)	1.05 (0.9, 1.21)	0.97 (0.89, 1.15)	0.575

^aP < 0.05;

¹All values: Median (Q1-Q3);

²Overall P-value from Kruskal-Wallis test or Fisher’s exact test, after testing with Dunn’s method for multiple comparisons;

³Normal vs FAT groups;

⁴Normal vs FIB groups;

⁵FAT vs FIB groups;

⁶n = 7, 77, 19 for the normal, FAT, and FIB groups, respectively. FAT: Fatty liver; FIB: Fibrotic liver; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; PDFF: MR proton density fat fraction; MRE: MR elastography; ADC: Apparent diffusion coefficient.

Citation: Shin HJ, Yoon H, Kim MJ, Han SJ, Koh H, Kim S, Lee MJ. Liver intravoxel incoherent motion diffusion-weighted imaging for the assessment of hepatic steatosis and fibrosis in children. World J Gastroenterol 2018; 24(27): 3013-3020
URL: https://www.wjgnet.com/1007-9327/full/v24/i27/3013.htm
DOI: https://dx.doi.org/10.3748/wjg.v24.i27.3013