Timing of surgery after neoadjuvant chemotherapy for gastric cancer: Impact on outcomes

Table 3 Multivariable analysis identifying independent predictors of overall survival and disease-free survival

Independent predictor	3-yr estimate (overall survival)			3-yr estimate (disease-free survival)
	HR	95%CI	P value	HR	95%CI	P value
NACT-Surgery interval time
< 4 wk vs > 6 wk	0.49	0.11-2.129	0.340	0.43	0.10-1.85	0.258
4-6 wk vs > 6 wk	0.99	0.24-4.06	0.985	0.93	0.23-3.80	0.922
Age
≤ 60 vs > 60	0.90	0.34-2.37	0.833	0.84	0.32-2.19	0.720
Sex
Female vs male	1.27	0.40-4.04	0.688	1.24	0.39-3.99	0.716
Histology (before NACT)
Tubular adenocarcinoma vs mixed type	2.56	0.24-26.94	0.433	2.25	0.22-22.56	0.491
Mucinous vs mixed type	3.79	0.21-70.55	0.372	3.12	0.18-53.99	0.435
Signet ring cell vs mixed type	5.71	0.40-81.22	0.199	4.99	0.37-66.54	0.224
Differentiation (before NACT)
Well and moderate vs poor	2.49	0.99-6.24	0.052	2.45	0.98-6.11	0.054
Clinical T stage
T2 vs T4	1.51	0.42-5.39	0.524	1.67	0.48-5.84	0.422
T3 vs T4	0.99	0.31-3.16	0.980	0.98	0.31-3.11	0.968
Clinical N stage
Positive vs negative	0.45	0.13-1.62	0.221	0.49	0.14-1.74	0.270
Tumor diameter (before NACT)
≤ 2 cm vs ≥ 5 cm	3.16	0.61-16.45	0.171	2.88	0.57-14.65	0.202
2-5 cm vs ≥ 5 cm	1.91	0.72-5.10	0.196	1.74	0.65-4.65	0.267
Tumor location
Upper vs diffuse type	1.04	0.15-7.33	0.973	0.99	0.14-6.98	0.989
Middle vs diffuse type	1.11	0.16-7.78	0.915	1.16	0.17-8.05	0.879
Lower vs diffuse type	4.41	0.78-25.18	0.095	3.94	0.69-22.50	0.123
Surgical procedure
Proximal gastrectomy vs total gastrectomy	0.69	0.17-2.73	0.593	0.79	0.20-3.07	0.729
Distal gastrectomy vs total gastrectomy	0.12	0.33-0.42	0.001	0.13	0.36-0.44	0.001
ypT stage
T0 vs T4	1.04	0.15-7.20	0.968	1.27	0.18-9.08	0.811
T1 vs T4	0.57	0.09-4.14	0.601	0.588	0.86-4.04	0.589
T2 vs T4	1.15	0.24-5.53	0.858	1.29	0.26-6.46	0.756
T3 vs T4	0.60	0.15-2.09	0.387	0.59	0.16-2.18	0.425
ypN stage
N0 vs N3	0.16	0.37-0.70	0.015	0.11	024-0.52	0.005
N1 vs N3	0.14	0.02-0.81	0.029	0.17	0.02-0.71	0.020
N2 vs N3	0.47	0.11-1.98	0.302	0.40	0.09-1.67	0.208

NACT: Neoadjuvant chemotherapy.