Colonic lesion characterization in inflammatory bowel disease: A systematic review and meta-analysis

Table 1 Study characteristics

Authors	Year	Abstract/article	Technology	Number of endoscopists	Study design	Real time vs Image review	No. of Patients	No. of Polyps	Mucosal classification method
Virtual Chromoendoscopy
Cassinotti et al[22]	2016	Abstract	i-scan HD	/	Single centre/prospective cohort	Real time	40	287	Kudo PP + other endoscopic features
					Prospective cohort
Efthymiou et al[21]	2013	Article	NBI HD	2	Single centre/prospective cohort	Real time	44	121	Kudo PP + low level magnification
Van den broek et al[23]	2011	Article	NBI HD	4	Single centre/randomized cross-over	Real time	48	153	Kudo PP
Cassinotti et al[24]	2015	Abstract	FICE HD	1	Single centre/randomized parallel	Real time	41	261	Kudo PP
Cassinotti et al[25]	2015	Abstract	FICE HD	1	Single centre/prospective cohort	Real time	59	205	Kudo PP
Dye-based Chromoendoscopy
Carballal et al[26]	2016	Article	IC 0.4% SD/HD	15	Multi-centre/prospective cohort	Real time	350	595	Kudo PP + 10 other items
1Buchner et al[27]	2016	Abstract	MB 0.1% HD	/	Prospective cohort	Real time	22	21	/
2Wanders et al[20]	2016	Article	MB 0.1% SD	> 1	Multi-centre/prospective cohort	Real time	61	66	Kudo PP
Munoz et al [28]	2016	Abstract	IC 0.2%-0.4% HD	> 1	Multi-centre/retrospective cohort	Real time	243	953	Kudo PP
Wanders et al[29]	2015	Article	MB 0.1% or IC 0.3%	17	Multi-centre/retrospective questionnaire	Image review	/	30	/
3Hlavaty et al [18]	2011	Article	IC 0.4% SD	2	Single centre/prospective cohort	Real time	30	100	Kudo PP
Confocal Laser Endomicroscopy
2Wanders et al[20]	2016	Article	iCLE	> 1	Multi-centre/prospective cohort	Real time	61	60	Mainz criteria
Dlugosz et al[30]	2016	Article	pCLE	1 endoscopist (2 reviewed images)	Single centre/retrospective cohort	Image review	69	644	Crypt + vessel architecture
1Buchner et al[27]	2016	Abstract	pCLE	/	Prospective cohort	Real time	22	20	Miami classification
Freire et al[31]	2014	Article	iCLE	1	Single centre/randomized trial	Real time	72	104	Mainz criteria
Rispo et al[32]	2012	Article	pCLE	1	Single centre/prospective cohort	Real time	51	15	De Palma classification
Shahid et al[33]	2011	Abstract	pCLE	3 reviewed images	Single centre/retrospective cohort	Image review	25	61	/
3Hlavaty et al[18]	2011	Article	iCLE	2	Single centre/prospective cohort	Real time	30	68	Mainz classification
4Van den broek et al[19]	2011	Article	pCLE	4 endoscopists (2 reviewing images)	Single centre/retrospective cohort	Image review	22	48	Crypt + vessel architecture
Keisslich et al[34]	2007	Article	iCLE	/	Single centre/randomized trial	Real time	80	134	Mainz classification
Magnification endoscopy
Nishiyama et al[35]	2016	Article	NBI	5 reviewed images	Single centre/retrospective cohort	Image review	27	33	Surface + vessel patterns
4Van den broek et al[19]	2011	Article	NBI	4	Single centre/prospective cohort	Real time	22	48	Kudo PP + vascular patterns
Van den broek et al[36]	2008	Article	NBI	3	Single centre/randomized trial	Real time	50	98	Kudo PP
Matsumoto et al[37]	2007	Article	NBI	1	Single centre/prospective cohort	Real time	46	296	Surface structure
Keisslich et al[38]	2003	Article	MB 0.1%	1	Single centre/randomized trial	Real time	84	118	Kudo PP
Studies using combined technologies
Bisschops et al[39]	2013	Abstract	Dye-based chromo/NBI	10 reviewed images	Multi-centre / Retrospective cohort	Image review	27	50	Kudo PP

List of studies included in meta-analysis and displayed according to technology type. PP: Pit pattern; /: Data missing.

¹Two different technologies from same abstract;

²Two different technologies from same article;

³Two different technologies from same article;

⁴Two different technologies from the same article.