Autoantibody profiles in autoimmune hepatitis and chronic hepatitis C identifies similarities in patients with severe disease

Table 5 Comparison of different parameters in chronic hepatitis C with and without autoantibodies (mean ± SD)

Parameters	CHC with autoantibodies	CHC without autoantibodies	P value
	M/F (9/9)	M/F (17/15)
Mean age (yr)	33 ± 16	34 ± 14.3	0.36 NS
Viral load (copy/mL)	8.3 × 105± 10.4 × 106	3 × 106± 19 × 105	0.52 NS
Duration of infection (mo)	21.3 ± 12.3	11 ± 7.3	0.0022
IgG (mg/dL)	2109 ± 462.4	1630 ± 323	0.0011
IgM (mg/dL)	190 ± 25	172 ± 45.3	0.3 NS
AP (U/L)	428 ± 91.5	221 ± 104	0.0011
AST (U/L)	52 ± 12.7	41 ± 9.81	0.0071
ALT (U/L)	36 ± 9.7	27 ± 7.2	0.0071
S. Albumin (g/dL)	3.8 ± 0.87	3.9 ± 0.72	0.47 NS
TSB (mg/dL)	1.5 ± 3.1	0.8 ± 0.58	0.0011

^1,2Indicate significant difference on the 0.01 and the 0.001 level respectively, NS indicates non-significance. Statistically significant differences were determined using analysis of variance followed by Duncan’s test. CHC: Chronic hepatitis C; AIH: Autoimmune hepatitis; AP: Alkaline phosphatase; AST: Aspartate transaminase; TSB: Total serum bilirubin; ALT: Alanine transaminase.