Study of the effects of nesfatin-1 on gastric function in obese rats

Figure 1 Changes in gastric acid secretion in rats. A: Intracerebroventricular injection; B: Intravenous injection. Rats were randomly assigned into 30 groups based on drug dosage and representative time points after administration. In each group, 15 rats were intracerebroventricularly injected with the drug, while the remaining 15 rats were intravenously injected with the drug. X axis: drug dosage; Y axis: time points after drug administration; Z axis: gastric acid secretory capacity, which was presented as the height of the histogram with its corresponding color (capacity: black < white < yellow < orange < gray). As shown in Figure 1B, the gastric acid secretion level of rats in the 1.0 μg/5 μL nesfatin-1 group reached 358.85 μmoL two hours after intravenous injection. This level was much lower than that in rats at zero-hour after intravenous injection (618.27 μmoL). The difference was statistically significant (P = 0.000). ^cP < 0.001, ^bP < 0.05; NS: No significant difference.