Recent advances in mass spectrometry-based proteomics of gastric cancer

Table 2 Cell line-based summary of recent proteomic analyses of gastric cancer

Cell line	Ref.	Aim of study	Proteins analyzed	Validation1
AGS	Holland et al[43], 2011	Phosphoproteome upon H. pylori infection	20 altered in abundance by H. pylori	No
	Loei et al[51], 2011	Secretome of AGS and MKN7	43 differed	IHC/WB
	Guo et al[68], 2012	Plasma membrane proteome	1473 identified	IHC
	Hou et al[69], 2013	Biomarkers for GC metastasis	19 increased and 34 decreased in metastasis	IHC/WB
	Hu et al[72], 2013	Global profile of miR-148a-regulated proteins	55 altered by miR-148a	WB
	Marimuthu et al[33], 2013	Secretome	263 increased and 45 decreased in GC	IHC
	Yu et al[57], 2013	Interactome of VCP	288 putative partners, including 18 PI3K/Akt proteins	WB
	Glowinski et al[42], 2014	Tyrosine signaling upon H. pylori transfection	85 altered by H. pylori	No
	Goh et al[60], 2015	Membrane proteome of 11 GC cell lines	882 altered, including 57 increased in ≥ 6 cell lines	WB
	Lin et al[61], 2015	Tanshinone IIA regulation	102 altered by tanshinone IIA treatment	WB
BGC-823	Cai et al[71], 2013	Effects of curcumin on viability and apoptosis	75 altered by curcumin treatment	No
HGC-27	Goh et al[60], 2015	Membrane proteome of 11 GC cell lines	882 altered, including 57 increased in ≥ 6 cell lines	WB
	Qiao et al[62], 2015	Proteomes of three GC cell lines	9 altered	IHC/WB
	Chen et al[77], 2016	Proteome with FAF1 or H. pylori	157 altered by FAF1, 500 by H. pylori and 246 by both	WB
MGC-803	Qiao et al[62], 2015	Proteomes of three GC cell lines	9 altered	IHC/WB
MKN7	Loei et al[51], 2011	Secretome of AGS and MKN7	43 differed	IHC/WB
	Guo et al[68], 2012	Plasma membrane proteome	1473 identified	IHC
	Yang et al[70], 2012	Membrane proteome	175 altered	IHC/WB
MKN45	Hu et al[13], 2013	Proteome changes following CXCR1 knockdown	16 increased and 13 decreased by CXCR1 knockdown	WB
	Yang et al[67], 2014	Proteome changes following NAIF1 overexpression	5 increased and 3 decreased by NAIF1 overexpression	WB
	Goh et al[60], 2015	Membrane proteome of 11 GC cell lines	882 altered, including 57 increased in ≥ 6 cell lines	WB
SGC-7901	Li et al[47], 2013	Cell surface glycoproteome of MDR	11 altered in MDR cell lines	WB
	Goh et al[60], 2015	Membrane proteome of 11 GC cell lines	882 altered, including 57 increased in ≥ 6 cell lines	WB
	Qiao et al[62], 2015	Proteomes of three GC cell lines	9 altered	IHC/WB

¹Validation indicates whether a selected set of altered proteins have been validated using immunohistochemistry (IHC) or Western blot (WB) or have not been (No). The cell line studies are listed in the order of publication year and then in alphabetical order by the first author. CXCR1: C-X-C chemokine receptor type 1; FAF1: Fas-associated factor 1; GC: Gastric cancer; H. pylori: Helicobacter pylori; MDR: Multidrug resistance; NAIF1: Nuclear apoptosis-inducing factor 1; VCP: Valosin-containing protein.