Combination antiretroviral studies for patients with primary biliary cirrhosis

Figure 2 Variations in MMTV pol gene were observed after 12 wk lamivudine/zidovudine therapy in the NOD. c3c4 mouse. Alignment of amino acid sequence 136-198 of MMTV Pol P03365.2 using ClustalW alignment (MacVector 11.1 software) showing the amino acid variations W150R, R176G, Y183H, M188V and L192P in five clones derived from two mice treated with lamivudine/zidovudine that were not observed in control mice on placebo. Variants G160S and D181N were observed in mice receiving placebo and antiretroviral therapy. With permission from Sharon et al[8].