Lymphocyte-to-monocyte ratio predicts survival of patients with hepatocellular carcinoma after curative resection

Table 2 Cox proportional hazards model of prognostic factors for overall survival in 210 patients with hepatocellular carcinoma after curative hepatectomy

Variable	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Age (yr), ≥ 60 vs < 60	0.766 (0.410-1.433)	0.404
Gender, male vs female	0.829 (0.296-2.321)	0.721
Liver cirrhosis, yes vs no	7.641 (1.853-31.509)	0.005	7.084 (1.694-29.614)	0.007
ALT (U/L), > 75 vs ≤ 75	1.513 (0.771-2.970)	0.229
Total bilirubin (μmol/L), > 34 vs ≤ 34	2.085 (0.822-5.288)	0.122
Albumin (g/L), ≥ 35 vs < 35	0.242 (0.112-0.522)	< 0.001
ALP (U/L), > 100 vs ≤ 100	2.116 (1.148-3.899)	0.016	2.137 (1.153-3.964)	0.016
AFP (ng/dL), > 400 vs ≤ 400	0.956 (0.535-1.705)	0.878
Tumor size (cm), > 5 vs ≤ 5	2.154 (1.204-3.853)	0.010
Tumor number, multiple vs single	1.048 (0.444-2.477)	0.915
Portal vein thrombus: yes vs no	3.348 (1.492-7.512)	0.003
Microvascular invasion: yes vs no	2.121 (1.151-3.911)	0.016	2.307 (1.217- 4.370)	0.010
Histological differentiation, poor vs well and moderate	2.888 (1.467-5.684)	0.002	2.375 (1.195-4.721)	0.014
BCLC stage, B + C vs 0 + A	2.110 (1.197-3.720)	0.010	2.155 (1.213-3.831)	0.009
Preoperative LMR, > 3.23 vs ≤ 3.23	0.352 (0.199-0.623)	< 0.001	0.398 (0.219-0.725)	0.003

AFP: Alpha-fetoprotein; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase; BCLC: Barcelona Clinic Liver Cancer; LMR: Lymphocyte-to-monocyte ratio.