Berberine inhibits hepatic gluconeogenesis via the LKB1-AMPK-TORC2 signaling pathway in streptozotocin-induced diabetic rats

Figure 7 Berberine inhibited expression of key gluconeogenic enzyme proteins. Western blot analyses of PEPCK and G-6-P proteins in liver tissues of normal rats, model rats and diabetic rats treated with berberine, AICAR or metformin. A: PEPCK blots for each group are shown; C: G-6-P blots for each group are shown; B: Each bar is expressed as the total PEPCK/β-actin and represents the mean ± SD (n = 8); D: Each bar is expressed as the total G-6-P/β-actin and represents the mean ± SD (n = 8). ^bP < 0.01 vs normal control group; ^dP < 0.01 vs model group; ^aP < 0.05 vs normal control group; ^cP < 0.05 vs model group (by ANOVA).