Impression of prognosis regarding pathologic stage after preoperative chemoradiotherapy in rectal cancer

Table 2 Univariate and multivariate cox proportional hazards regression models of the clinical factors associated with recurrence-free survival in preoperative chemoradiotherapy patients with pathologically- proven metastatic lymph nodes

Factor	Univariate analysis			Multivariate analysis
	HR	95%CI	P value	HR	95%CI	P value
Sex			0.41
Male	1.00
Female	0.85	0.57-1.25
Age (yr)	1.00	0.98-1.02	0.89
Lymphovascular invasion			0.54
None	1.00
Present	1.28	0.83-1.98
Perineural invasion			0.01			0.02
None	1.00			1.00
Present	1.89	1.22-2.95		1.82	1.15-2.87
Sphincter preservation			0.01			0.93
No	1.00			1.00
Yes	0.60	0.40-0.89		0.96	0.35-2.59
Tumor grade			0.34
G1, G2	1.00
G3, G4	1.31	0.75-2.31
Preoperative CEA			0.45
Normal	1.00
Increased	1.22	0.73-2.05
Location of tumor			0.25			0.89
Mid-rectum	1.00
Lower rectum	1.26	0.85-1.87		1.03	0.66-1.62
Number of retrieved lymph node	0.97	0.95-1.01	0.14
Adjuvant chemotherapy1			0.36			0.46
Same1	1.00			1.00
Altered	0.72	0.35-1.47		0.76	0.36-1.58

¹Same: same regimen as that used for preoperative concurrent chemoradiotherapy. Altered: Second-line regimen was different from that used for preoperative chemotherapy; CEA: Carcinoembryonic antigen.