Cytoprotective effects of amifostine, ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats

Figure 1 Methotrexate-induced effects on hepatic structure in rats. Photomicrographs of representative liver tissues are shown for the control group (A) and model group (B-D). A: Normal histological appearence of H-E stained control liver tissues, showing vena centralis (VC) at × 40; B: Abnormal histological appearance of H-E stained model liver tissues, showing hepatocytes with eosinophilic cytoplasm around the portal area (arrows) at × 40; C: Inflammatory cells in the portal area (arrows) and congestion at × 40 (arrowhead); and D: Hydropic degeneration (vacuolization/cellular swelling) in hepatocytes at × 40.