Regulation of microRNA by hepatitis B virus infection and their possible association with control of innate immunity

Table 1 MicroRNAs associated with Toll-like receptor signaling pathways, upregulated by 5-fold or greater in HepG2.2.15 than in HepG2

MicroRNAs	Genomic location	Fold changes	Description of target molecules/pathways	Ref.
miR-200b-3p	1p36.33	140.15	TLR4 signaling through MyD88-dependent pathway	[47]
miR-148a-3p	7p15.2	73.36	TLR3, TLR4 and TLR9 agonists upregulated miR-148/152 expression	[48]
miR-145-5p	5q32	66.97	miR-145 promoted interferon-β induction by SOCS7	[49]
miR-146b-5p	10q24.32	20.05	TNF receptor-associated factor 6 and IL-1 receptor-associated kinase 1	[50]
miR-200c-3p	12p13.31	10.75	TLR4 signaling through MyD88-dependent pathway	[47]
miR-455-3p	9q32	7.36	miR-455 was involved in TLR4 signaling pathway through E2F1 transcription factor	[51]
miR-455-5p	9q32	5.76	miR-455 was involved in TLR4 signaling pathway through E2F1 transcription factor	[51]

Genomic location was analyzed using GeneCards (http://gene4.weizmann.ac.il/). TLR: Toll-like receptor.