Routine diagnosis of intestinal tuberculosis and Crohn's disease in Southern India

Table 1 Inclusion and exclusion criteria for study participants

Criteria
Inclusion criteria
Intestinal tuberculosis (as per modified Paustian’s criteria[31,32]: (a), and one or more of (b) and (c) had to be fulfilled)	(a) Endoscopic apparent intestinal tuberculosis: transverse ulcers, pseudopolyps, involvement of fewer than four intestinal segments, patulous ileo-coecal valve (b) Histological evidence of tubercles/granulomas with caseation necrosis in intestinal biopsies (c) Clinical response to antituberculous chemotherapeutic drug treatment (ATT) trial
Crohn’s disease (as per ECCO guidelines 2010[33] and management consensus of inflammatory bowel disease for the Asia-Pacific region 2006[34])	Exclusion of infectious enterocolitis Endoscopic: ileal disease, rectal sparing, confluent deep linear ulcers, aphthoid ulcers, deep fissures, fistulae, skip lesions (segmental disease), cobble-stoning Histological: focal (discontinuous) chronic (lymphocytes and plasma cells) inflammation and patchy chronic inflammation, focal crypt irregularity (discontinuous crypt distortion) and granulomas (not related to crypt injury) Samples from ileum: irregular villous architecture
Exclusion criteria
Malignancy
HIV positive
Age below 18 yr