Long-term aspirin pretreatment in the prevention of cerulein-induced acute pancreatitis in rats

Figure 3 Cytokine levels, lipid peroxidation and white blood cells. A: Cerulein induced acute pancreatitis (AP) caused a marked elevation of interleukin (IL)-1β level in pancreatic tissue compared to that of the reference values (RV) group (18.81 ± 2.55 and 6.65 ± 0.24 pg/μg, respectively, P = 0.002); B: This elevation was suppressed significantly by acetylsalicylic acid (ASA) in all treatment groups. A similar increase was observed in the pancreatic IL-6 level. However, this time, the low-dose seemed to be ineffective against it, while medium- and high-dose ASA pretreatments suppressed the IL-6 elevation. There was no statistical difference between the groups regarding the tumor necrosis factor-α and nuclear factor-κB levels; C, D: Cerulein induced AP increased malondialdehyde (MDA) levels in both pancreatic tissue and plasma compared to that of the RV group; E: Cerulein induced AP increased the peripheral white blood cell (WBC) count significantly compared to the RV group. HD: High-dose; MD: Medium-dose; LD: Low-dose; APC: Acute pancreatitis control.