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World J Gastroenterol. May 21, 2013; 19(19): 2894-2903
Published online May 21, 2013. doi: 10.3748/wjg.v19.i19.2894
Published online May 21, 2013. doi: 10.3748/wjg.v19.i19.2894
Long-term aspirin pretreatment in the prevention of cerulein-induced acute pancreatitis in rats
Ibrahim Akyazi, Evren Eraslan, Elif Ergül Ekiz, Deniz Aktaran Bala, Erdal Matur, Mukaddes Özcan, Department of Physiology, Veterinary Faculty, Istanbul University, 34320 Istanbul, Turkey
Ahmet Gülçubuk, Damla Haktanir, Department of Pathology, Veterinary Faculty, Istanbul University, 34320 Istanbul, Turkey
Zeynep L Çırakli, Department of Biochemistry, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, 34147 Istanbul, Turkey
Mete Özkurt, Department of Physiology, Faculty of Medicine, Eskişehir Osmangazi University, 26480 Eskisehir, Turkey
Author contributions: Akyazi I planned the study, conducted the project, and performed the cytokine, aspirin-triggered lipoxins and nuclear factor-κB analyses; Eraslan E helped to plan the project, and performed the NO and Catalase analyses; Gülçubuk A conducted the histopathological scoring; Ekiz EE performed the hemeoxygenase-1 and superoxide dismutase analyses; Çırakli ZL analyzed the biochemical parameters; Haktanir D performed the histopathological preparation of tissues and scoring; Bala DA and Özkurt M collected the samples; Matur E helped to plan the project and conducted the malondialdehyde analysis; Özcan M supervised the project.
Supported by The Istanbul University Department of Scientific Research Projects, Grant No. 3101
Correspondence to: Ibrahim Akyazi, DVM, PhD, Department of Physiology, Veterinary Faculty, Istanbul University, 34320 Istanbul, Turkey. iakyazi@istanbul.edu.tr
Telephone: +90-536-9690720 Fax: +90-212-4737218
Received: November 14, 2012
Revised: January 23, 2013
Accepted: February 5, 2013
Published online: May 21, 2013
Revised: January 23, 2013
Accepted: February 5, 2013
Published online: May 21, 2013
Core Tip
Core tip: Acute pancreatitis (AP) is an inflammatory and potentially life-threatening disease. An estimated 80000 cases of AP occur each year in the United States. There is no specific cure for AP; therefore, research interest has focused on prevention strategies. In the present study, the effects of a long-term pretreatment with different doses of aspirin, the oldest and most widely used non-steroidal anti-inflammatory drug, were investigated on a AP model in rats. Our results indicated that aspirin pretreatment dose-dependently prevents or ameliorates some hematological, serological and histological alterations caused by cerulein-induced AP.