Expression of interleukin-22/STAT3 signaling pathway in ulcerative colitis and related carcinogenesis

Figure 1 Expression and distribution of interleukin-22 and its related proteins in colonic biopsy specimens as analyzed by immunohistochemistry (× 200). A1-A4: Expression and distribution of interleukin (IL)-22 in colonic biopsy specimens from the control, inactive ulcerative colitis (UC), mild-moderate UC, and severe UC tissues, respectively; B1-B4: The expression and distribution of IL-23 in colonic biopsy specimens from the control, inactive UC, mild-moderate UC, and severe UC tissues; C1-C4: The expression and distribution of IL-22R1 in colonic biopsy specimens from the control, inactive UC, mild-moderate UC, and severe UC tissues; D1-D4: The expression and distribution of p-STAT3 (S727) in colonic biopsy specimens from the control, inactive UC, mild-moderate UC, and severe UC tissues.