Present and future of prophylactic antibiotics for severe acute pancreatitis

Table 1 Recent meta-analyses on the outcomes of prophylactic antibiotics for severe acute pancreatitis

Meta-analysis	Year	No. of RCTs	Mortality		Infected necrosis		Recommendation
			Effect size	95% CI	Effect size	95% CI
Jafri et al[15]	2009	8	RR = 0.76	(0.49, 1.16)	RR = 0.79	(0.56, 1.11)	Unfavorable
Xu et al[16]	2008	8	RR = 0.76	(0.50, 1.18)	RR = 0.69	(0.50, 0.95)a	Pending
Bai et al[17]	2008	7	RR = 0.70	(0.42, 1.17)	RR = 0.81	(0.54, 1.22)	Unfavorable
Hart et al[18]	2008	7	OR = 0.71	(0.41, 1.23)	OR = 0.72	(0.45, 1.16)	Unfavorable
de Vries et al[19]	2007	6	ARR = 0.058	(-0.017, 0.134)	ARR = 0.055	(-0.084, 0.194)	Pending
Dambrauskas et al[20]	2007	10	RR = 0.76	(0.586, 0.976)	RR = 0.57	(0.418, 0.784)a	Pending
Villatoro et al[21]	2006	5	OR = 0.37	(0.17, 0.83)a	OR = 0.62	(0.35, 1.09)	Pending
Mazaki et al[22]	2006	6	RR = 0.78	(0.44, 1.39)	RR = 0.77	(0.54, 1.12)	Unfavorable
Xiong et al[23]	2006	6	RR = 0.54	(0.28, 1.04)	RR = 0.77	(0.48, 1.24)	Unfavorable

^aP < 0.05 antibiotic prophylaxis vs placebo/none; RCT: Randomized controlled trial; CI: Confidence interval; RR: Risk ratio; OR: Odds ratio; ARR:Absolute risk reduction.