Agmatine induces gastric protection against ischemic injury by reducing vascular permeability in rats

Figure 2 Histological appearance of the gastric mucosa of HE stained sections of the studied groups. A: Sham-operated showing intact mucosa; B: Gastric ischemia reperfusion (I/R) showing hemorrhages, edema and ulceration; C: Agmatine (AGM) treated group (100 mg/kg, i.p. prior to I/R) with marked preservation of gastric mucosa and disappearance of ulceration and hemorrhages; D: Effect of inhibition of Akt/phosphatidyl inositol-3-kinase (PI3K) (wortmannin 15 μg/kg, i.p.) prior to AGM treatment, showing extensive lesions and salvage of gastric mucosa into the lumen (× 20 magnification).